Department of Biological Sciences
Indian Institute of Science Education and Research Bhopal


Personal Details


  • Name: Dr. Himanshu Kumar
  • Designation: Associate Professor
  • Department: Biological Sciences
  • E-Mail: hkumar[AT]iiserb.ac.in
  • Phone: +91 755 269 1413, 669 1413
  • Lab Page: Click Here


Awards and Fellowships


  • Awarded Ramanujan Fellowship from Department of Science and Technology, Government of India (July 2010-).
  • Awarded Kishimoto Foundation Fellowship from WPI Immunology Frontier Research Center, Osaka University (April 2010-June 2010).
  • Awarded Japan Society for the Promotion of Science (JSPS) Post-doctoral Fellowship from Government of Japan (April 2008-March 2010).
  • Awarded Japanese Government Scholarship (MEXT) from Government of Japan (April 2003-March 2008) for pursuing doctoral thesis.

Academic Details


  • Associate Professor (August 2016-till date), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
  • Assistant Professor (July 2010-July 2016), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
  • Adjunct Associate Professor. (March 2010-till date),World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan.
  • JSPS Post-doctoral Fellow (April 2008-March 2010), Laboratory of Host Defense, World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan.
  • Ph.D.[April 2004-March 2008 as Japanese Government Fellow (MEXT Fellow)], Immunobiology, Graduate School of Medicine, Osaka University, Japan with Professor. Shizuo Akira.

Research Interest


  • Innate immunity is first line of defense system and promptly activated after microbial infection to initiate protective responses through production of inflammatory cytokines from various immune cells. Innate immune system consists of humoral components such as complements, acute phase proteins and cellular components such as Monocytes, Macrophages, Dendritic cells, Eosinophils, Basophils, Neutrophils, Mast cells and Natural-killer cells. The humoral components have a broad range of actions against microorganisms, including gram-positive and gram-negative bacteria, fungi and viruses. The cellular components either directly kill the microbial pathogens through phagocytosis or induce production of cytokines, which helps in the elimination of pathogens. The innate immune cells express various pattern recognition receptors (PRRs) which recognize signature molecules of the pathogen. These signature molecules are essential for the survival of the pathogen and known as a pathogen associated molecular pattern (PAMPs). These PRRs recognizes different PAMPs of the pathogen in various compartments of the cells and trigger induction of inflammatory cytokines for the host defense. Furthermore, the innate immune responses are also required for the development of the pathogen specific adaptive immunity through B and T lymphocytes.
  • The aims of our group are: To identify new innate receptors or adaptor or signaling molecules through various screening systems and characterize the identified genes in vitro and in vivo.
  • To integrate the basic knowledge of innate immune signaling pathways to the susceptibility with human infectious disease.
  • To study the cross-talk and diverse regulation of various innate signaling pathways.
  • To integrate the basic knowledge of PAMPs, PRRs and innate immune signaling pathways in development of ideal vaccine adjuvant.
Authors Title of Article Journal Year
Himanshu Kumar
Adrian Bot
Role of immune cells, immune modulating factors and immunotoxins in cancer immunotherapy International Reviews in Immunology 2017
Himanshu Kumar
Adrian Bot
Role of MicroRNAs in shaping innate immunity and as therapeutic targets for autoimmune diseases International Reviews in Immunology 2017
Himanshu Kumar
Adrian Bot
Innate immunity and infectious diseases–An update International Reviews in Immunology 2017
Himanshu Kumar
Adrian Bot
Antibodies in pathogenesis and management of diseases International Reviews in Immunology 2017
Puja Kumari
Himanshu Kumar
Viral Deubiquitinases: Role in Evasion of Anti-viral Innate Immunity Critical Reviews in Microbiology 2017
Shalabh Mishra
Himanshu Kumar
Balancing Anti-viral innate immunity and immune homeostasis Cellular & molecular Immunology 2017
Puja Kumari
Irene Saha
Athira Narayanan
Sathish Narayanan
Akinori Takaoka
Nachimuthu Senthil Kumar
Prafullakumar Tailor
Himanshu Kumar
Essential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways Cell Death and Disease 2017
Mohan Reddy Bodireddy
Ranjeet Singh Mahla
P Md Khaja Mohinuddin
G Trivikram Reddy
D Vijaya Raghav Prasad
Himanshu Kumar
Discovery of a new class of 16-membered (2Z, 11Z)-3, 11-di (aryl/naphthyl)-1, 13-dioxa-5, 9-dithia-2, 12-diazacyclohexadeca-2, 11-dienes as anti-tumor agents RSC Advances 2016
Pradip B Ranaware
Anamika Mishra
Periyasamy Vijakumar
Pradip N Gandhale
Himanshu Kumar
Diwakar D Kulkarni
Ashwin Ashok Raut
Genome Wide Host Gene Expression Analysis in Chicken Lungs Infected with Avian Influenza Viruses PLoS One 2016
Mohammed Fawaz
Periyasamy Vijaykumar
Anamika Mishra
Pradip N Gandhale
Rupam Dutta
Nitin M Kamble
Shashi B Sudhakar
Parimal Roychoudhary
Himanshu Kumar
Diwakar D Kulkarni
Ashwin Ashok Raut
Duck gut viral metagenome analysis captures snapshot of viral diversity. BMC Genomics 2016
Puja Kumari
Sathish Narayanan
Himanshu Kumar
Herpesviruses: interfering innate immunity by targeting viral sensing and interferon pathways Reviews in Medical Virology 2015
Sushil Kumar
Harshad Ingle
Shalabh Mishra
Ranjeet Singh Mahla
Ashish Kumar
Taro Kawai
Shizuo Akira
Akinori Takaoka
Ashwin Ashok Raut
Himanshu Kumar
IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependnt and independent anticancer activity Cell Death and Disease 2015
Harshad Ingle
Sushil Kumar
Ashwin Ashok Raut
Anamika MIshra
Diwakar Dattatraya Kulkarni
Takeshi Kameyama
Akinori Takaoka
Shizuo Akira
Himanshu Kumar
The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication Science Signaling 2015
Raunaq Singh Nagi
Ashish Shekhar Bhat
Himanshu Kumar
Cancer: a tale of aberrant PRR response Frontiers in Immunology 2014
Deepak Bharti
Ashish Kumar
Ranjeet Singh Mahla
Sushil Kumar
Harshad Ingle
Hari Shankar
Beenu Joshi
Ashwin Ashok Raut
Himanshu Kumar
The role of TLR9 polymorphism in susceptibility to pulmonary tuberculosis Immunogenetics 2014
Ranjit Singh Mahla
Madhawa C Reddy
D. Vijaya Raghava Prasad
Himanshu Kumar
Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology Frontiers in Immunology 2013
Sushil Kumar
Harshad Ingle
DVR Prasad
Himanshu Kumar
Recognition of Bacterial Infection by Innate Immune Sensors. Critical Reviews in Microbiology Critical Reviews in Microbiology 2013
Himanshu Kumar
Adrian Bot
Innate immune recognition mechanism and Translational Opportunities, an Editorial for special issue International Reviews in Immunology 2013
Himanshu Kumar
Taro Kawai
Shizuo Akira
Pathogen Recognition by the Innate Immune System International Reviews in Immunology 2011

Post-Doctoral Fellow


  • Deepak

Graduate Students


  • Harshad Ingle
  • Sushil Kumar