Department of Biological Sciences
Indian Institute of Science Education and Research Bhopal

Personal Details

  • Name: Dr. Varun Chaudhary
  • Designation: Assistant Professor
  • Department: Biological Sciences
  • E-Mail: varun.c[AT]
  • Phone: +91 755 269 1421

Awards and Fellowships

  • Ramalingaswamy Fellowship by Department of Biotechnology (April 2017)

Academic Details

  • Assistant Professor (June 2015 onwards): Indian Institute of Science, Education and Research (IISER) Bhopal
  • Postdoctoral Fellow (2010-2015): German Cancer Research Center Heidelberg Germany
  • PhD (2005- 2009): Dept. of Biomedical sciences, University of Sheffield.

Research Interest

  • Functional analysis of Wnt signaling pathways in development, tissue patterning and diseases. Secreted Wnt proteins plays a pivotal role in development and progression of disease like colorectal cancer. Work done mainly in Drosophila melanogaster (Fruit fly) over last 3 decades has identified several well-conserved molecular players of the Wnt protein mediated signalling pathways, however we are still far from understanding the mechanisms by which these signalling pathways regulate tissue growth and patterning. Particularly their role in patterning polarized epithelial tissues remains unknown.

    We are using the Drosophila model to understand the processes regulating epithelial patterning. We use combinations of cell and developmental biology tools to investigate how Wnt proteins are secreted and how they regulating patterning of epithelial tissue.
  • Understand mechanisms of Wnt protein secretion and signalling in polarized epithelium.
  • To solve the issue of how Wnt morphogens regulate tissue growth and patterning.
  • Investigate the relationship between Wnt signalling and intracellular vesicle trafficking.
Authors Title of Article Journal Year
Pranab Kumar Paul
Shruti Umarvaish
Shivani Bajaj
Rishana Farin S
Hrudya Mohan
Wim Annaert
Varun Chaudhary
Maintenance of proteostasis by Drosophila Rer1 is essential for competitive cell survival and Myc-driven overgrowth PLOS Genetics 2024
Shefali Mehta
Swapnil Hingole
Varun Chaudhary
The Emerging Mechanisms of Wnt Secretion and Signaling in Development Frontiers in Cell and Developmental Biology 2021
Anirban Das
Yogesh M. Gangarde
Viniti Tomar
Omkar Shinde
Tulsi Upadhyay
Sarfaraz Alam
Sudipta Ghosh
Varun Chaudhary
Ishu Saraogi
Small-Molecule Inhibitor Prevents Insulin Fibrillogenesis and Preserves Activity Molecular Pharmaceutics 2020
Varun Chaudhary
Michael Boutros
Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium PLOS Genetics 2019
Varun Chaudhary
Swapnil Hingole
Jana Frei
Fillip Port
David Strutt
Michael Boutros
Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing Development 2019

Open Positions

I am looking for a Junior Research Fellow to work on understanding the mechanisms of Wnt protein secretion in Drosophila. Interested candidates may write directly to me at with cover letter describing personal qualifications and research interests and Curriculum vitae with name and contact details of two-three references

Eligible candidates should hold a master degree (or equivalent) in a relevant discipline including Biotechnology/ Biochemistry/Life Sciences or any other related field.

Although not necessary, candidates with experience in microscopy, image analysis, molecular biology and genetics are encouraged to apply.

Current lab members

Post-doctoral Fellow
  • Khusboo Kashyap (
PhD Students
  • Viniti Tomar (
  • Juilee Sabnis (
  • Pranab K. Paul (
  • Swapnil Hingole (
Current BS-MS project students
  • Subham Biswas (
  • Rounak Chaurasia (

Past Members

  • Midhun Mohan M (BS-MS)
  • Arvind Meena (BS-MS)
  • Himanshu Teta (BS-MS)