Department of Biological Sciences
Indian Institute of Science Education and Research Bhopal


Personal Details


  • Name: Dr. Ajit Chande
  • Designation: Assistant Professor
  • Department: Biological Sciences
  • E-Mail: ajitg@iiserb.ac.in
  • Phone: +91 755 269 1431


Academic Details


  • Assistant Professor (May 2017-till date), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
  • Postdoctoral Fellow (July 2014-April 2017), Centre for Integrative Biology, University of Trento, Italy
  • Research Scientist (Jan 2012-June 2014), Immunology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi.
  • Ph.D. (August 2006-December 2011), Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Navi Mumbai.
  • Although the host has sophisticated antiviral signaling programs to inhibit viral replication, viruses seem to have evolved strategies to subvert these defenses. This arms race therefore provides an opportunity to understand how viruses evolve and develop possibilities to therapeutically target the host-virus interface to reduce the disease burden. We have recently identified a cellular factor SERINC5 that potently inhibits retroviruses. This host-factor has a broad spectrum activity and three different retroviruses (HIV, MLV and EIAV) have developed countermeasures to inhibit this host restriction. We are currently trying to understand such cell-intrinsic mechanisms of viral inhibition and investigating the existence of anti-retroviral barriers.
  • Based on the strengths in cellular engineering and assay development, our research group is also interested in developing innovative molecular technology enabling novel approaches to study, diagnose and treat diseases. We exploit the CRISPR/Cas9 genome editing technologies for our own research interests in viral pathogenesis, and in collaboration with experts within and outside of India. For development and exploitation of our technologies in other fields, we collaborate intensively. At the moment, our strategic technology development focuses on cellular engineering as a basis for the discovery and development of novel biopharmaceuticals.
Authors Title of Article Journal Year
Pavitra Ramdas
Vipin Bhardwaj
Aman Singh
Nagarjun Vijay
Ajit Chande
Coelacanth SERINC2 inhibits HIV-1 infectivity and is counteracted by envelope glycoprotein from foamy virus Journal of Virology 2021
Aditi Choudhary
Pratibha Madbhagat
M. Sreepadmanabh
Vipin Bhardwaj
Ajit Chande
Circular RNA as an Additional Player in the Conflicts Between the Host and the Virus Frontiers in Immunology 2021
Amit Sahu
Sreepadmanabh M
Mahendra Rai
Ajit Chande
SARS-CoV-2: phylogenetic origins, pathogenesis, modes of transmission, and the potential role of nanotechnology VirusDisease 2021
Tarun Mishra
Sreepadmanabh M
Pavitra Ramdas
Amit K Sahu
Atul Kumar
Ajit Chande
SARS CoV-2 Nucleoprotein Enhances the Infectivity of Lentiviral Spike Particles Frontiers in Cellular and Infection Microbiology 2021
Sreepadmanabh M
Amit Kumar Sahu
Ajit Chande
COVID-19: Advances in Diagnostic Tools, Treatment Strategies, and Vaccine Development Journal of Biosciences 2020
Pavitra Ramdas
Amit Kumar Sahu
Tarun Mishra
Vipin Bhardwaj
Ajit Chande
From entry to egress: Strategic exploitation of the cellular processes by HIV-1 Frontiers in Microbiology 2020
Richa Mishra
Sanjana Bhattacharya
Bhupendra Singh Rawat
Ashish Kumar
Akhilesh Kumar
Kavita Niraj
Ajit Chande
Puneet Gandhi
Dheeraj Khetan
Amita Aggarwal
Seiichi Sato
Prafullakumar Tailor
Akinori Takaoka
Himanshu Kumar
MicroRNA-30e-5p has an integrated role in the regulation of the innate immune response during virus infection and systemic lupus erythematosus iScience 2020
MD. Waseem Hussain
Vipin Bhardwaj
Arkaprabha Giri
Ajit Chande
Abhijit Patra
Functional Ionic Porous Frameworks Based on Triaminoguanidinium for CO2 Conversion and Combating Microbes Chemical Science 2020
Amol Gade
Pradip Bagle
Popat Shinde
Vipin Bhardwaj
Subhrashis Banerjee
Ajit Chande
Nitin Patil
Catalytic Enantioselective 1, 3‐Alkyl Shift in Alkyl Aryl Ethers: Efficient Synthesis of Optically Active 3, 3′‐Diaryloxindoles Angewandte Chemie International Edition 2018
Nagarjun Vijay
Ajit Chande
A hypothetical new role for single-stranded DNA binding proteins in the immune system Immunobiology 2018
Claudia Firrito
Cinzia Bertelli
Teresa Vanzo
Ajit Chande
Massimo Pizzato
SERINC5 as a New Restriction Factor for Human Immunodeficiency Virus and Murine Leukemia Virus Annual Review of Virology 2018
Ajit Chande
Claudia Firrito
Massimo Pizzato
SERINC5: not all splice variants work against HIV Journal of Public Health and Emergency 2017

Open Positions


The lab is inviting applications through “the SERB-National Post Doctoral Fellowship (N-PDF) program” and looking for a highly motivated postdoctoral researcher who is interested in studying mechanistic aspects of cell-intrinsic restrictions to viruses, evolutionary aspects of virus biology, and improving genome editing platforms for developing disease models. Candidates not from biology backgrounds are also encouraged to contact with the proposal and their CV with cover letter by email to me at ajitg@iiserb.ac.in.


Desirable: Prior experience with cell/molecular biology techniques and analysis of next-generation sequencing data.


Resources

  • HIV-1/HIV2 based lentiviral vector platforms for in vitro and in vivo transgenesis.
  • CRISPR/Cas9 design, viral/non-viral delivery approaches for genome editing.
  • Sub-cellular fluorescent genetic markers for microscopy.