Personal Details
- Name: Prof. Himanshu Kumar
- Designation: Professor
- Department: Biological Sciences
- E-Mail: hkumar[AT]iiserb.ac.in
- Phone: +91 755 269 1413
- Lab Page: Click Here
Awards and Fellowships
- Awarded Ramanujan Fellowship from Department of Science and Technology, Government of India (July 2010-).
- Awarded Kishimoto Foundation Fellowship from WPI Immunology Frontier Research Center, Osaka University (April 2010-June 2010).
- Awarded Japan Society for the Promotion of Science (JSPS) Post-doctoral Fellowship from Government of Japan (April 2008-March 2010).
- Awarded Japanese Government Scholarship (MEXT) from Government of Japan (April 2003-March 2008) for pursuing doctoral thesis.
Academic Details
- Associate Professor (August 2016-till date), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
- Assistant Professor (July 2010-July 2016), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
- Adjunct Associate Professor. (March 2010-till date),World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan.
- Associate/ Section Editor (May 2012 - till date), International Reviews of Immunology, Informa Healthcare press.
- JSPS Post-doctoral Fellow (April 2008-March 2010), Laboratory of Host Defense, World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan.
- Ph.D.[April 2004-March 2008 as Japanese Government Fellow (MEXT Fellow)], Immunobiology, Graduate School of Medicine, Osaka University, Japan with Professor. Shizuo Akira.
Research Interest
-
Innate immunity is first line of defense system and promptly activated after microbial infection to initiate protective responses through production of inflammatory cytokines from various immune cells. Innate immune system consists of humoral components such as complements, acute phase proteins and cellular components such as Monocytes, Macrophages, Dendritic cells, Eosinophils, Basophils, Neutrophils, Mast cells and Natural-killer cells. The humoral components have a broad range of actions against microorganisms, including gram-positive and gram-negative bacteria, fungi and viruses. The cellular components either directly kill the microbial pathogens through phagocytosis or induce production of cytokines, which helps in the elimination of pathogens. The innate immune cells express various pattern recognition receptors (PRRs) which recognize signature molecules of the pathogen. These signature molecules are essential for the survival of the pathogen and known as a pathogen associated molecular pattern (PAMPs). These PRRs recognizes different PAMPs of the pathogen in various compartments of the cells and trigger induction of inflammatory cytokines for the host defense. Furthermore, the innate immune responses are also required for the development of the pathogen specific adaptive immunity through B and T lymphocytes.
- The aims of our group are: To identify new innate receptors or adaptor or signaling molecules through various screening systems and characterize the identified genes in vitro and in vivo.
- To integrate the basic knowledge of innate immune signaling pathways to the susceptibility with human infectious disease.
- To study the cross-talk and diverse regulation of various innate signaling pathways.
- To integrate the basic knowledge of PAMPs, PRRs and innate immune signaling pathways in development of ideal vaccine adjuvant.
| Authors | Title of Article | Journal | Year |
|---|---|---|---|
| Pandikannan Krishnamoorthy Athira S Raj Himanshu Kumar |
Machine learning-driven blood transcriptome-based discovery of SARS-CoV-2 specific severity biomarkers | Journal of Medical Virology | 2023 |
| Pandikannan Krishnamoorthy Athira S Raj Pramod Kumar Nilanjana Das Himanshu Kumar |
Host and viral non-coding RNAs in dengue pathogenesis | Reviews in Medical Virology | 2022 |
| Himanshu Kumar Puja Kumari |
Dimensions of inflammation in host defense and diseases | International Reviews of Immunology | 2022 |
| Himanshu Kumar |
How metabolism and metabolites shape immunity during disease | International Reviews of Immunology | 2022 |
| Akhilesh Kumar Shalabh Mishra Ashish Kumar Ashwin Ashok Raut Seiichi Sato Akinori Takaoka Himanshu Kumar |
Essential role of Rnd1 in innate immunity during viral and bacterial infections | Cell Death and Disease | 2022 |
| Shalabh Mishra Athira S Raj Akhilesh Kumar Ashwathi Rajeevan Puja Kumari Himanshu Kumar |
Innate Immune Sensing of Influenza A Viral RNA Through IFI16 Promotes Pyroptotic Cell Death | iScience | 2022 |
| Himanshu Kumar |
Components of specific immunity in host defense | International Reviews of Immunology | 2021 |
| Himanshu Kumar |
Cancer and Immunity: who is shaping whom? | International Reviews of Immunology | 2021 |
| Himanshu Kumar |
Immune-mediated organ pathologies of vital organs | International Reviews of Immunology | 2021 |
| Pandikannan Krishnamoorthy Athira S. Raj Swagnik Roy Nachimuthu Senthil Kumar Himanshu Kumar |
Comparative transcriptome analysis of SARS-CoV, MERS-CoV, and SARS-CoV-2 to identify potential pathways for drug repurposing | Computers in Biology and Medicine | 2021 |
| Ranjeet Singh Mahla Akhilesh Kumar Helena J Tutill Sreevidhya Tarakkad Krishnaji Bharathwaj Sathyamoorthy Mahdad Noursadeghi Judith Breuer Amit Kumar Pandey Himanshu Kumar |
NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial infection | Tuberculosis | 2021 |
| Richa Mishra Pandikannan Krishnamoorthy Himanshu Kumar |
MicroRNA-30e-5p Regulates SOCS1 and SOCS3 During Bacterial Infection | Frontiers in Cellular and Infection Microbiology | 2021 |
| Annesa Das Kuldeep Singh Chauhan Himanshu Kumar Prafullakumar Tailor |
Mutation in Irf8 Gene (Irf8R294C) Impairs Type I IFN-Mediated Antiviral Immune Response by Murine pDCs | Frontiers in Immunology | 2021 |
| Himanshu Kumar |
Immune-mediated organ pathologies of vital organs | International Reviews of Immunology | 2021 |
| Himanshu Kumar |
Cancer and immunity: who is shaping whom? | International Reviews of Immunology | 2021 |
| Himanshu Kumar |
Components of specific immunity in host defense | International Reviews of Immunology | 2021 |
| Himanshu Kumar |
Sentinels of innate immunity in disease pathogenesis and development of therapeutics | International Reviews of Immunology | 2021 |
| Akhilesh Kumar Nilanjana Das Himanshu Kumar |
COVert IDentities of current worldwide pandemic | International Reviews of Immunology | 2021 |
| Irene Saha Hemant Jaiswal Richa Mishra Hendrick J Nel Jaring Scheuder Monika Kaushik Kuldeep Singh Chauhan Bhupendra Singh Rawat Renjeny THomas Shalin Naik Himanshu Kumar Prafullakumar Tailor |
RelB suppresses type I Interferon signaling in dendritic cells | Cellular Immunology | 2020 |
| Himanshu Kumar |
Balancing immune tolerance and immune responses | International Reviews of Immunology | 2020 |
| Himanshu kumar |
Therapeutic approaches for genetic and infectious diseases | International Reviews of Immunology | 2020 |
| Richa Mishra Sanjana Bhattacharya Bhupendra Singh Rawat Ashish Kumar Akhilesh Kumar Kavita Niraj Ajit Chande Puneet Gandhi Dheeraj Khetan Amita Aggarwal Seiichi Sato Prafullakumar Tailor Akinori Takaoka Himanshu Kumar |
MicroRNA-30e-5p has an Integrated Role in the Regulation of the Innate Immune Response during Virus Infection and Systemic Lupus Erythematosus | iScience | 2020 |
| Richa Mishra Pandikannan Krishnamoorthy S.Gangamma Ashwin Ashok Raut Himanshu Kumar |
Particulate matter (PM10) enhances RNA virus infection through modulation of innate immune responses | Environmental Pollution | 2020 |
| Richa Mishra Ashish Kumar Harshad Ingle Himanshu Kumar |
The Interplay Between Viral-Derived miRNAs and Host Immunity During Infection | Frontiers in Immunology | 2020 |
| Himanshu Kumar |
Approaches for deciphering the molecular basis of disease and its translational benefits | International Reviews of Immunology | 2019 |
| Akhilesh Kumar Himanshu Kumar |
Long noncoding RNA: TRIMming the viral load | Cellular & molecular Immunology | 2019 |
| Himanshu Kumar |
Immunity and its role in white plague and obesity | International Reviews of Immunology | 2019 |
| Amit Awasthi Himanshu Kumar |
T cell subtypes and its therapeutic potential in autoimmune diseases and cancer | International Reviews of Immunology | 2019 |
| MIhai Oltean Himanshu Kumar |
Donor-specific antibodies and organ transplantation: a dangerous mix | International Reviews of Immunology | 2019 |
| Himanshu Kumar |
Host defense: basic, disease and translational biology | International Reviews of Immunology | 2019 |
| Ashish Kumar Akhilesh Kumar Harshad Ingle Sushil Kumar Richa Mishra Mahendra Kumar Verma Debasis Biswas Nachimuthu Senthil Kumar Anamika Mishra Ashwin Askok Raut Akinori Takaoka Himanshu Kumar |
MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2 | Journal of Virology | 2018 |
| Debajyoti Sinha Akhilesh Kumar Himanshu Kumar Sanghamitra Bandyopadhyay Debarka Sengupta |
dropClust: efficient clustering of ultra-large scRNA-seq data | Nucleic Acids Research | 2018 |
| Himanshu Kumar |
Evolution of innate immune sensors and responses during immune disorders and immunization against microbial infection | International Reviews of Immunology | 2018 |
| Himanshu Kumar Adrian Bot |
Role of immune cells, immune modulating factors and immunotoxins in cancer immunotherapy | International Reviews of Immunology | 2017 |
| Himanshu Kumar Adrian Bot |
Role of MicroRNAs in shaping innate immunity and as therapeutic targets for autoimmune diseases | International Reviews of Immunology | 2017 |
| Himanshu Kumar Adrian Bot |
Innate immunity and infectious diseases–An update | International Reviews of Immunology | 2017 |
| Himanshu Kumar Adrian Bot |
Antibodies in pathogenesis and management of diseases | International Reviews of Immunology | 2017 |
| Puja Kumari Himanshu Kumar |
Viral Deubiquitinases: Role in Evasion of Anti-viral Innate Immunity | Critical Reviews in Microbiology | 2017 |
| Shalabh Mishra Himanshu Kumar |
Balancing Anti-viral innate immunity and immune homeostasis | Cellular & molecular Immunology | 2017 |
| Puja Kumari Irene Saha Athira Narayanan Sathish Narayanan Akinori Takaoka Nachimuthu Senthil Kumar Prafullakumar Tailor Himanshu Kumar |
Essential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways | Cell Death and Disease | 2017 |
| Mohan Reddy Bodireddy Ranjeet Singh Mahla P Md Khaja Mohinuddin G Trivikram Reddy D Vijaya Raghav Prasad Himanshu Kumar |
Discovery of a new class of 16-membered (2Z, 11Z)-3, 11-di (aryl/naphthyl)-1, 13-dioxa-5, 9-dithia-2, 12-diazacyclohexadeca-2, 11-dienes as anti-tumor agents | RSC Advances | 2016 |
| Pradip B Ranaware Anamika Mishra Periyasamy Vijakumar Pradip N Gandhale Himanshu Kumar Diwakar D Kulkarni Ashwin Ashok Raut |
Genome Wide Host Gene Expression Analysis in Chicken Lungs Infected with Avian Influenza Viruses | PLoS One | 2016 |
| Mohammed Fawaz Periyasamy Vijaykumar Anamika Mishra Pradip N Gandhale Rupam Dutta Nitin M Kamble Shashi B Sudhakar Parimal Roychoudhary Himanshu Kumar Diwakar D Kulkarni Ashwin Ashok Raut |
Duck gut viral metagenome analysis captures snapshot of viral diversity. | BMC Genomics | 2016 |
| Puja Kumari Sathish Narayanan Himanshu Kumar |
Herpesviruses: interfering innate immunity by targeting viral sensing and interferon pathways | Reviews in Medical Virology | 2015 |
| Sushil Kumar Harshad Ingle Shalabh Mishra Ranjeet Singh Mahla Ashish Kumar Taro Kawai Shizuo Akira Akinori Takaoka Ashwin Ashok Raut Himanshu Kumar |
IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependnt and independent anticancer activity | Cell Death and Disease | 2015 |
| Harshad Ingle Sushil Kumar Ashwin Ashok Raut Anamika MIshra Diwakar Dattatraya Kulkarni Takeshi Kameyama Akinori Takaoka Shizuo Akira Himanshu Kumar |
The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication | Science Signaling | 2015 |
| Raunaq Singh Nagi Ashish Shekhar Bhat Himanshu Kumar |
Cancer: a tale of aberrant PRR response | Frontiers in Immunology | 2014 |
| Deepak Bharti Ashish Kumar Ranjeet Singh Mahla Sushil Kumar Harshad Ingle Hari Shankar Beenu Joshi Ashwin Ashok Raut Himanshu Kumar |
The role of TLR9 polymorphism in susceptibility to pulmonary tuberculosis | Immunogenetics | 2014 |
| Ranjit Singh Mahla Madhawa C Reddy D. Vijaya Raghava Prasad Himanshu Kumar |
Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology | Frontiers in Immunology | 2013 |
| Sushil Kumar Harshad Ingle DVR Prasad Himanshu Kumar |
Recognition of Bacterial Infection by Innate Immune Sensors. Critical Reviews in Microbiology | Critical Reviews in Microbiology | 2013 |
| Himanshu Kumar Adrian Bot |
Innate immune recognition mechanism and Translational Opportunities, an Editorial for special issue | International Reviews of Immunology | 2013 |
| Himanshu Kumar Taro Kawai Shizuo Akira |
Pathogen Recognition by the Innate Immune System | International Reviews of Immunology | 2011 |
Post-Doctoral Fellow
- Deepak
Graduate Students
- Harshad Ingle
- Sushil Kumar