Department of Biological Sciences
Indian Institute of Science Education and Research Bhopal


Personal Details


  • Name: Dr. Swagata Ghatak
  • Designation: Assistant Professor
  • Department: Biological Sciences
  • E-Mail: swagata[AT]iiserb.ac.in
  • Phone: +91 755 269 1439


Academic Details


  • Assistant Professor- Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal; 2021- present.
  • Postdoctoral associate: Department of Molecular Medicine, The Scripps Research Institute, California, USA; 2017-2021.
  • Postdoctoral associate: Neurodegenerative Disease Center, Scintillon Institute, California, USA; 2016-2017.
  • Ph.D.: in Neuroscience and Biophysics, Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India; 2008-2016.
  • M.Sc.: Biophysics and Molecular Biology, University college of Science and Technology, University of Calcutta, Kolkata, India; 2006-2008.

Research Interest


  • Elucidating pathophysiological mechanisms of neurological disorders.
  • Creating novel brain models using human induced pluripotent stem cells (hiPSCs) from patients to study neurological disorders.
  • Translating novel mechanisms to develop therapy against neurological diseases.
  • Picture: Cerebral organoid generated from hiPSCs of an Alzheimer’s Disease patient.
Authors Title of Article Journal Year
Dorit Trudler
Sara Sanz-Blasco
Yvonne S Eisele
Swagata Ghatak
Karthik Bodhinathan
Mohd Waseem Akhtar
William P Lynch
Juan C Pina-Crespo
Maria Talantova
Jeffery W Kelly
Stuart A Lipton
Alpha-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss Journal of Neuroscience 2021
Elaine Pirie
Chang-ki Oh
Xu Zhang
Xuemei Han
Piotr Cieplak
Henry R Scott
Amanda K Deal
Swagata Ghatak
Fernando J Martinez
Gene W Yeo
John R Yates
Tomohiro Nakamura
Stuart A Lipton
S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD Proceedings of the National Academy of Sciences 2021
Swagata Ghatak
Dorit Trudler
Nima Dolatabadi
hiPSC maintenance and differentiation Bio-protocol 2020
Swagata Ghatak
Maria Talantova
Scott R McKercher
Stuart A Lipton
Novel Therapeutic Approach for Excitatory Inhibitory Imbalance in Neurodevelopmental and Neurodegenerative Diseases Annual Review of Pharmacology and Toxicology 2020
Swagata Ghatak
Nima Dolatabadi
Richard Gao
Yin Wu
Henry Scott
Dorit Trudler
Abdullah Sultan
Rajesh Ambasudhan
Tomohiro Nakamura
Eliezer Masliah
Maria Talantova
Bradley Voytek
Stuart A Lipton
NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models Molecular Psychiatry 2020
Dorit Trudler
Swagata Ghatak
James Parker
Maria Talantova
Titas Grabauskas
Sarah Moore Noveral
Mayu Teranaka
Melissa Luevanos
Nima Dolatabadi
Clare Bakker
Kevin Lopez
Abdullah Sultan
Agnes Chan
Yongwook Choi
Riki Kawaguchi
Nicholas Schork
Pawel Stankiewicz
Ivan Garcia-Bassets
Piotr Kozbial
Michael G Rosenfeld
Nobuki Nakanishi
Daniel Geschwind
Shing Fai Chan
Rajesh Ambasudhan
Stuart A Lipton
Aberrant gliogenesis and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids BioArxiv 2020
Swagata Ghatak
Nima Dolatabadi
Dorit Trudler
XiaoTong Zhang
Yin Wu
Madhav Mohata
Rajesh Ambasudhan
Maria Talantova
Stuart A Lipton
Mechanisms of hyperexcitability in Alzheimers disease hiPSC-derived neurons and cerebral organoids vs isogenic controls eLife 2019
Swagata Ghatak
Dorit Trudler
Nima Dolatabadi
Rajesh Ambasudhan
Parkinsons disease: what the model systems have taught us so far Journal of Genetics 2018
Vishal Metri
Swagata Ghatak
Soumyendu Raha
Sujit Sikdar
Patch clamp data driven stochastic modeling and simulation of hTREK1 potassium ion channel gating Chemical Physics 2018
Aditi Banerjee
Swagata Ghatak
Sujit Kumar Sikdar
L-Lactate mediates neuroprotection against ischaemia by increasing expression of TREK1 channels in rat hippocampal astrocytes in vitro. Journal of Neurochemistry 2016
Swagata Ghatak
Sujit Kumar Sikdar
Lactate modulates the intracellular pH sensitivity of human TREK1 channels Pflügers Archiv-European Journal of Physiology 2016
Swagata Ghatak
Aditi Banerjee
Sujit Kumar Sikdar
Ischaemic concentrations of lactate increase TREK1 channel activity by interacting with a single histidine residue in the carboxy terminal domain The Journal of Physiology 2015