Personal Details
- Name: Dr. R. Mahalakshmi
- Designation: Professor
- Department: Biological Sciences
- E-Mail: maha[AT]iiserb.ac.in
- Phone: +91 755 269 1423
Awards and Fellowships
- 2020 : DBT - Wellcome Trust India Alliance Senior Fellowship.
- 2020 : SwarnaJayanti Fellowship, Department of Science and Technology.
- 2020 : Young Researcher Award, Lady Tata Memorial Trust.
- 2020 : Featured in “Future of Biochemistry: The Asia-Pacific Issue”.
- 2019 : Indian Peptide Society - Young Scientist Award.
- 2019 : Exceptional Fellows Fund from Wellcome Trust - DBT India Alliance.
- 2017 : SERB Women Excellence Award
- 2015 - Present: Wellcome Trust/ DBT India Alliance Intermediate Fellow
- 2014 : NASI Young Scientist Platinum Jubilee Award, The National Academy of Sciences.
- 2014 - 2017 : Associate, Indian Academy of Sciences.
- 2014 : INSA Medal for Young Scientists, Indian National Science Academy.
- 2010 - 2015 : Innovative Young Biotechnologist Award (IYBA) from the Department of Biotechnology, Govt. of India.
- 2010 - 2015: Ramalingaswami Fellowship.
Academic Details
- 2021 June - Present : Professor, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
- 2014 - 2021 : Associate Professor, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
- 2009 - 2014 : Assistant Professor in the Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
- 2008 - 2009 : Postdoctoral Fellow in the Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, U.S.A.
- 2006 - 2008 : Postdoctoral Associate in the Department of Apoptosis and Cell Death Research, Sanford Burnham Prebys Medical Discovery Institute (previously Burnham Institute for Medical Research), La Jolla, CA, U.S.A.
- 2003 - 2006 : Ph. D. in Molecular Biophysics from the Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India, under the guidance of Prof. P. Balaram.
Information for New Candidates (PhD Program)
- We are keen on selecting candidates who are highly motivated and committed to research. Those who hold a valid CSIR-JRF/ UGC-JRF/ ICMR- category A/ DBT-JRF/ DST-INSPIRE or equivalent fellowship should contact Dr. Mahalakshmi (maha[at]iiserb.ac.in).
- Mitochondrial Membrane Protein Folding, Function, and Regulation.
- Membrane Protein Folding and Misfolding.
- Molecular Experimental Biophysics.
- For details, please click here
| Authors | Title of Article | Journal | Year |
|---|---|---|---|
| Anjana George Roshika Ravi Pankaj Tiwari Shashank Srivastava Vikas Jain Radhakrishnan Mahalakshmi |
Engineering a Hyperstable Yersinia pestis Outer Membrane Protein Ail Using Thermodynamic Design | Journal of the American Chemical Society | 2022 |
| Altmash Khan Gifty Kuriachan Radhakrishnan Mahalakshmi |
Cellular interactome of mitochondrial VDACs: Oligomerization and channel (mis)regulation. | ACS Chemical Neuroscience | 2021 |
| Muralikrishna Lella Radhakrishnan Mahalakshmi |
De novo Design of Metal Binding Cleft in a Trp-Trp Stapled Thermostable ?-Hairpin Peptide | Peptide Science | 2021 |
| Pankaj Tiwari Radhakrishnan Mahalakshmi |
Interplay of protein primary sequence, lipid membrane, and chaperone in ?-barrel assembly. | Protein Science | 2021 |
| Pankaj Tiwari Radhakrishnan Mahalakshmi |
Molecular Assembly Pathway of Mitochondrial Sam50 in Native Membranes. | Biophysical Journal | 2021 |
| Ankit Gupta Radhakrishnan Mahalakshmi |
Reversible folding energetics of Yersinia Ail barrel reveals a hyperfluorescent intermediate. | Biochim. Biophys. Acta (Biomembranes) | 2020 |
| Bharat Iyer Swadha Gupta Henna Noordeen Roshika Ravi Meera Pawar Anjana George Radhakrishnan Mahalakshmi |
Molecular Switch between Structural Compaction and Thermodynamic Stability by the Xxx?Pro Interface in Transmembrane ??Barrels | Biochemistry | 2020 |
| Ankit Gupta Radhakrishnan Mahalakshmi |
Single-residue physicochemical characteristics kinetically partition membrane protein self-assembly and aggregation | Journal of Biological Chemistry | 2020 |
| Radhakrishnan Mahalakshmi |
Oxidative Thiol Modifications as Molecular Redox Sensors in Human Mitochondria | Biophysical Journal | 2020 |
| William Rosencrans M Martin-Queralt Radhakrishnan Mahalakshmi Sergey Bezrukov Tatiana Rostovtseva |
Dynamic Plasticity of Mitochondrial VDAC2 Revealed by Single-Molecule Electrophysiology. | Biophysical Journal | 2020 |
| Shashank Srivastava Radhakrishnan Mahalakshmi |
Linking Folding Landscape with Function in the Human Mitochondrial VDAC2 | Biophysical Journal | 2020 |
| Radhakrishnan Mahalakshmi |
Do folding elements trade?off with function in the human mitochondrial metabolite transporter? | FASEB Journal | 2020 |
| Shashank Srivastava Radhakrishnan Mahalakshmi |
Evolutionary selection of a 19-stranded mitochondrial ?-barrel scaffold bears structural and functional significance | Journal of Biological Chemistry | 2020 |
| Radhakrishnan Mahalakshmi |
Aromatic Interactions in β-Hairpin Scaffold Stability: A Historical Perspective. | Arch. Biochem. Biophys | 2019 |
| Ankit Gupta Radhakrishnan Mahalakshmi |
Reversible folding energetics of Yersinia Ail barrel reveals a hyperfluorescent intermediate | Biochim. Biophys. Acta (Biomembranes) | 2019 |
| Ankit Gupta Radhakrishnan Mahalakshmi |
Helix–strand interaction regulates stability and aggregation of the human mitochondrial membrane protein channel VDAC3 | J. Gen. Physiol. | 2019 |
| Bharat Iyer Radhakrishnan Mahalakshmi |
Hydrophobic characteristic is energetically preferred for cysteine in a model membrane protein | Biophysical Journal | 2019 |
| Radhakrishnan Mahalakshmi |
Human Mitochondrial VDAC Functionality Governs Scaffold Stability. | Biophysical Journal | 2018 |
| Shashank Ranjan Srivastava Punit Zadafiya Radhakrishnan Mahalakshmi |
Hydrophobic mismatch modulates stability and plasticity of human mitochondrial VDAC2. | Biophysical Journal | 2018 |
| Deepti Chaturvedi Radhakrishnan Mahalakshmi |
Folding determinants of transmembrane β-barrels using engineered OMP chimeras | Biochemistry | 2018 |
| Muralikrishna Lella Radhakrishnan Mahalakshmi |
Direct Structural Annotation of Membrane Protein Aggregation Loci using Peptide–Based Reverse–Mapping | J. Phys. Chem. Lett. | 2018 |
| Bharat Iyer Pallavi Vetal Henna Noordeen Punit Zadafiya Radhakrishnan Mahalakshmi |
Salvaging the thermodynamic destabilization of interface histidine in transmembrane β-barrels | Biochemistry | 2018 |
| Deepti Chaturvedi Radhakrishnan Mahalakshmi |
Position–specific contribution of interface tryptophans on membrane protein energetics | Biochim. Biophys. Acta (Biomembranes) | 2018 |
| Muralikrishna Lella Radhakrishnan Mahalakshmi |
Solvation Driven Conformational Transitions in the Second Transmembrane Domain of Mycobacteriophage Holin. | Biopolymers | 2017 |
| Bharat Ramasubramanian Iyer Ankit Gupta Radhakrishnan Mahalakshmi |
Approaches for preparation and biophysical characterization of transmembrane β-barrels | Springer Protocols Handbooks | 2017 |
| Muralikrishna Lella Radhakrishnan Mahalakshmi |
Metamorphic Proteins: Emergence of dual protein folds from one primary sequence. | Biochemistry | 2017 |
| Bharat Iyer Punit Zadafiya Pallavi Vetal Radhakrishnan Mahalakshmi |
Energetics of side chain partitioning of β-signal residues in unassisted folding of a transmembrane β-barrel protein. | Journal of Biological Chemistry | 2017 |
| Svetlana Maurya Radhakrishnan Mahalakshmi |
Mitochondrial VDAC2 and cell homeostasis: highlighting hidden structural features and unique functionalities. | Biological Reviews | 2017 |
| Radhakrishnan Mahalakshmi Svetlana Maurya Bhavna Burdak Parini Surti Manoj Patel Vikas Jain |
Structural plasticity of T4 transcription co-activator gp33 revealed by a protease-resistant unfolded state | Biophysical and Biochemical Research Communication | 2017 |
| Deepti Chaturvedi Radhakrishnan Mahalakshmi |
Transmembrane β-barrels: Evolution, folding and energetics. | Biochim. Biophys. Acta (Biomembranes) | 2017 |
| Muralikrishna Lella Radhakrishnan Mahalakshmi |
Engineering a Transmembrane Nanopore Ion Channel from a Membrane Breaker Peptide. | The Journal of Physical Chemistry Letters | 2016 |
| Svetlana Maurya Radhakrishnan Mahalakshmi |
Control of human VDAC-2 scaffold dynamics by interfacial tryptophans is position specific. | Biochim. Biophys. Acta (Biomembranes) | 2016 |
| Simona Reina Vanessa Checchetto Rosaria Saletti Ankit Gupta Deepti Chaturvedi Carlo Guardiani Francesca Guarino Mariano Andrea Scorciapino Andrea Magrì Salvatore Foti Matteo Ceccarelli Angela Anna Messina Radhakrishnan Mahalakshmi Ildiko Szabo Vito De Pinto |
VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications. | Oncotarget | 2016 |
| Svetlana Rajkumar Maurya Radhakrishnan Mahalakshmi |
VDAC-2: Mitochondrial outer membrane regulator masquerading as a channel? | FEBS Journal | 2016 |
| Muralikrishna Lella Soumya Kamilla Vikas Jain Radhakrishnan Mahalakshmi |
Molecular Mechanism of Holin Transmembrane Domain I in Pore Formation and Bacterial Cell Death. | ACS Chemical Biology | 2016 |
| Kamlesh Madhusudan Makwana Radhakrishnan Mahalakshmi |
Stereopositional Outcome in the Packing of Dissimilar Aromatics in Designed beta-Hairpins | Chemistry - A European Journal | 2016 |
| Simona Reina Vanessa Checchetto Rosaria Saletti Ankit Gupta Deepti Chaturvedi Carlo Guardiani Francesca Guarino Mariano Andrea Scorciapino Andrea Magrì Salvatore Foti Matteo Ceccarelli Angela A. Messina Radhakrishnan Mahalakshmi Ildiko Szabo Vito De Pinto |
Unexpected Modifications of Cysteines in VDAC3: Indication that VDAC3 may Signal the Mitochondrial Intermembrane Redox State | Biophysical Journal | 2016 |
| Vito De Pinto Simona Reina Ankit Gupta Angela Messina Radhakrishnan Mahalakshmi |
Role of cysteines in mammalian VDAC isoforms' function. | Biochim. Biophys. Acta (Bioenergetics) | 2016 |
| Kamlesh Madhusudan Makwana Radhakrishnan Mahalakshmi |
Capping beta-Hairpin with N-terminal D-Amino Acid Stabilizes Peptide Scaffold. | Biopolymers | 2016 |
| Ankit Gupta Bharat Ramasubramanian Iyer Deepti Chaturvedi Svetlana Rajkumar Maurya Radhakrishnan Mahalakshmi |
Thermodynamic, structural and functional properties of membrane protein inclusion bodies are analogous to purified counterparts: Case study from bacteria and humans. | RSC Advances | 2015 |
| Kamlesh Makwana Radhakrishnan Mahalakshmi |
Nature of aryl-tyrosine interactions contribute to beta-hairpin scaffold stability: NMR evidence for alternate ring geometry. | Phys. Chem. Chem. Phys. | 2015 |
| Radhakrishnan Mahalakshmi |
Folding and stability of transmembrane beta-barrels of bacterial and human origin: Probing underlying similarities and principal differences using in vitro systems. | Proc. Indian Natn. Sci. Acad. | 2015 |
| Kamlesh Madhusudan Makwana Radhakrishnan Mahalakshmi |
NMR Analysis of Tuning Cross-Strand Phe/Tyr/Trp - Trp Interactions in Designed beta-Hairpin Peptides: Terminal Switch from L- to D-Amino Acid as a Strategy for beta-Hairpin Capping. | J. Phys. Chem. B | 2015 |
| Kamlesh Madhusudan Makwana Radhakrishnan Mahalakshmi |
Trp-Trp Cross-Linking: A Structure-Reactivity Relationship in the Formation and Design of Hyperstable Peptide beta-Hairpin and alpha-Helix Scaffolds. | Organic Letters | 2015 |
| Kamlesh Madhusudan Makwana Radhakrishnan Mahalakshmi |
Structure Stabilizing Role of Aromatic Interactions is Decided by Spatial Arrangement of Aromatic Pairs: A Case Study With Designed Peptide beta-Hairpins. | Peptides | 2015 |
| Bharat Ramasubramanian Iyer Radhakrishnan Mahalakshmi |
Residue-dependent thermodynamic cost and barrel plasticity balances activity in the PhoPQ-activated enzyme PagP of Salmonella typhimurium | Biochemistry | 2015 |
| Kamlesh Madhusudan Makwana Radhakrishnan Mahalakshmi |
Implications of Aromatic-Aromatic Interactions: From Protein Structures to Peptide Models. | Protein Science | 2015 |
| Svetlana Rajkumar Maurya Radhakrishnan Mahalakshmi |
N-helix and cysteines inter-regulate human mitochondrial VDAC-2 function and biochemistry. | Journal of Biological Chemistry | 2015 |
| Svetlana Rajkumar Maurya Radhakrishnan Mahalakshmi |
Influence of Protein - Micelle Ratios and Cysteine Residues on the Kinetic Stability and Unfolding Rates of Human Mitochondrial VDAC-2 | PLoS One | 2014 |
| Kamlesh Madhusudan Makwana Radhakrishnan Mahalakshmi |
Comparative analysis of cross strand aromatic-Phe interactions in designed peptide beta-hairpins. | Organic & Biomolecular Chemistry | 2014 |
| Svetlana Rajkumar Maurya Radhakrishnan Mahalakshmi |
Cysteine Residues Impact the Stability and Micelle Interaction Dynamics of the Human Mitochondrial beta-barrel Anion Channel hVDAC-2. | PLoS One | 2014 |
| Ravikiran Boddepalli Radhakrishnan Mahalakshmi |
Unusual post-translational protein modifications : The benefits of sophistication. | RSC Advances | 2014 |
| Ankit Gupta Punit Zadafiya Radhakrishnan Mahalakshmi |
Differential Contribution of Tryptophans to the Folding and Stability of the Attachment Invasion Locus Transmembrane beta-Barrel from Yersinia pestis. | Scientific Reports | 2014 |
| Kamlesh Madhusudan Makwana Radhakrishnan Mahalakshmi |
Asymmetric contribution of aromatic interactions stems from spatial positioning of the interacting aryl pairs in beta-hairpins | ChemBioChem | 2014 |
| Deepti Chaturvedi Radhakrishnan Mahalakshmi |
Juxtamembrane tryptophans possess distinct roles in defining the OmpX barrel-micelle boundary and packing-facilitated protein-micelle association | FEBS Lett. | 2014 |
| Svetlana Rajkumar Maurya Deepti Chaturvedi Radhakrishnan Mahalakshmi |
Modulating lipid dynamics and membrane fluidity to drive rapid folding of a transmembrane barrel | Scientific Reports | 2013 |
| Svetlana Rajkumar Maurya Radhakrishnan Mahalakshmi |
Modulation of human mitochondrial voltage-dependent anion channel 2 (hVDAC-2) structural stability by cysteine-assisted barrel-lipid interactions. | Journal of Biological Chemistry | 2013 |
| Kamlesh Madhusudan Makwana SR Raghothama Radhakrishnan Mahalakshmi |
Stabilizing effect of electrostatic vs aromatic interactions in diproline nucleated peptide beta-hairpins. | Phys. Chem. Chem. Phys. | 2013 |
| Muralikrishna Lella Radhakrishnan Mahalakshmi |
Pro-Gly mediated conformational switch of Mycobacteriophage D29 holin transmembrane domain I is lipid concentration driven. | Chemical Communications | 2013 |
| Deepti Chaturvedi Radhakrishnan Mahalakshmi |
Methionine Mutations of Outer Membrane Protein X Influence Structural Stability and beta-Barrel Unfolding. | PLoS One | 2013 |
| Ankit Gupta Deepti Chaturvedi Radhakrishnan Mahalakshmi |
Modified CNBr cleavage protocol for efficient separation of Met-Ser containing OmpX-Om14 membrane protein fusion | Intl. Rev. Biophys. Chem. | 2012 |
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