Department of Biological Sciences
Indian Institute of Science Education and Research Bhopal


Personal Details


  • Name: Dr. R. Mahalakshmi
  • Designation: Associate Professor
  • Department: Biological Sciences
  • E-Mail: maha[AT]iiserb.ac.in
  • Phone: +91 755 269 1423


Awards and Fellowships


  • 2019 : Indian Peptide Society - Young Scientist Award.
  • 2019 : Exceptional Fellows Fund from Wellcome Trust - DBT India Alliance.
  • 2017 : SERB Women Excellence Award
  • 2015 - Present: Wellcome Trust/ DBT India Alliance Intermediate Fellow
  • 2014 : NASI Young Scientist Platinum Jubilee Award, The National Academy of Sciences.
  • 2014 - 2017 : Associate, Indian Academy of Sciences.
  • 2014 : INSA Medal for Young Scientists, Indian National Science Academy.
  • 2010 - 2015 : Innovative Young Biotechnologist Award (IYBA) from the Department of Biotechnology, Govt. of India.
  • 2010 - 2015: Ramalingaswami Fellowship.

Academic Details


  • 2014 Sep - Present : Associate Professor, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
  • 2009 - 2014 : Assistant Professor in the Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
  • 2008 - 2009 : Postdoctoral Fellow in the Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, U.S.A.
  • 2006 - 2008 : Postdoctoral Associate in the Department of Apoptosis and Cell Death Research, Sanford-Burnham Medical Research Institute (previously Burnham Institute for Medical Research), La Jolla, CA, U.S.A.
  • 2003 - 2006 : Ph. D. in Molecular Biophysics from the Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India, under the guidance of Prof. P. Balaram.

Information for New Candidates (PhD Program)


  • We are keen on selecting candidates who are highly motivated and committed to research. Those who hold a valid CSIR-JRF/ UGC-JRF/ ICMR- category A/ DBT-JRF/ DST-INSPIRE or equivalent fellowship should contact Dr. Mahalakshmi (maha[at]iiserb.ac.in).
  • Mitochondrial Membrane Protein Folding, Function, and Regulation.
  • Membrane Protein Folding and Misfolding.
  • Molecular Experimental Biophysics.
  • For details, please click here
Authors Title of Article Journal Year
Radhakrishnan Mahalakshmi
Aromatic Interactions in β-Hairpin Scaffold Stability: A Historical Perspective. Arch. Biochem. Biophys 2019
Radhakrishnan Mahalakshmi
Human Mitochondrial VDAC Functionality Governs Scaffold Stability. Biophysical Journal 2018
Shashank Ranjan Srivastava
Punit Zadafiya
Radhakrishnan Mahalakshmi
Hydrophobic mismatch modulates stability and plasticity of human mitochondrial VDAC2. Biophysical Journal 2018
Deepti Chaturvedi
Radhakrishnan Mahalakshmi
Folding determinants of transmembrane β-barrels using engineered OMP chimeras Biochemistry 2018
Muralikrishna Lella
Radhakrishnan Mahalakshmi
Direct Structural Annotation of Membrane Protein Aggregation Loci using Peptide–Based Reverse–Mapping J. Phys. Chem. Lett. 2018
Bharat Iyer
Pallavi Vetal
Henna Noordeen
Punit Zadafiya
Radhakrishnan Mahalakshmi
Salvaging the thermodynamic destabilization of interface histidine in transmembrane β-barrels Biochemistry 2018
Deepti Chaturvedi
Radhakrishnan Mahalakshmi
Position–specific contribution of interface tryptophans on membrane protein energetics Biochim. Biophys. Acta (Biomembranes) 2018
Muralikrishna Lella
Radhakrishnan Mahalakshmi
Solvation Driven Conformational Transitions in the Second Transmembrane Domain of Mycobacteriophage Holin. Biopolymers 2017
Bharat Ramasubramanian Iyer
Ankit Gupta
Radhakrishnan Mahalakshmi
Approaches for preparation and biophysical characterization of transmembrane β-barrels Springer Protocols Handbooks 2017
Muralikrishna Lella
Radhakrishnan Mahalakshmi
Metamorphic Proteins: Emergence of dual protein folds from one primary sequence. Biochemistry 2017
Bharat Iyer
Punit Zadafiya
Pallavi Vetal
Radhakrishnan Mahalakshmi
Energetics of side chain partitioning of β-signal residues in unassisted folding of a transmembrane β-barrel protein. Journal of Biological Chemistry 2017
Svetlana Maurya
Radhakrishnan Mahalakshmi
Mitochondrial VDAC2 and cell homeostasis: highlighting hidden structural features and unique functionalities. Biological Reviews 2017
Radhakrishnan Mahalakshmi
Svetlana Maurya
Bhavna Burdak
Parini Surti
Manoj Patel
Vikas Jain
Structural plasticity of T4 transcription co-activator gp33 revealed by a protease-resistant unfolded state Biophysical and Biochemical Research Communication 2017
Deepti Chaturvedi
Radhakrishnan Mahalakshmi
Transmembrane β-barrels: Evolution, folding and energetics. Biochim. Biophys. Acta (Biomembranes) 2017
Muralikrishna Lella
Radhakrishnan Mahalakshmi
Engineering a Transmembrane Nanopore Ion Channel from a Membrane Breaker Peptide. The Journal of Physical Chemistry Letters 2016
Svetlana Maurya
Radhakrishnan Mahalakshmi
Control of human VDAC-2 scaffold dynamics by interfacial tryptophans is position specific. Biochim. Biophys. Acta (Biomembranes) 2016
Simona Reina
Vanessa Checchetto
Rosaria Saletti
Ankit Gupta
Deepti Chaturvedi
Carlo Guardiani
Francesca Guarino
Mariano Andrea Scorciapino
Andrea Magrì
Salvatore Foti
Matteo Ceccarelli
Angela Anna Messina
Radhakrishnan Mahalakshmi
Ildiko Szabo
Vito De Pinto
VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications. Oncotarget 2016
Svetlana Rajkumar Maurya
Radhakrishnan Mahalakshmi
VDAC-2: Mitochondrial outer membrane regulator masquerading as a channel? FEBS Journal 2016
Muralikrishna Lella
Soumya Kamilla
Vikas Jain
Radhakrishnan Mahalakshmi
Molecular Mechanism of Holin Transmembrane Domain I in Pore Formation and Bacterial Cell Death. ACS Chemical Biology 2016
Kamlesh Madhusudan Makwana
Radhakrishnan Mahalakshmi
Stereopositional Outcome in the Packing of Dissimilar Aromatics in Designed beta-Hairpins Chemistry - A European Journal 2016
Simona Reina
Vanessa Checchetto
Rosaria Saletti
Ankit Gupta
Deepti Chaturvedi
Carlo Guardiani
Francesca Guarino
Mariano Andrea Scorciapino
Andrea Magrì
Salvatore Foti
Matteo Ceccarelli
Angela A. Messina
Radhakrishnan Mahalakshmi
Ildiko Szabo
Vito De Pinto
Unexpected Modifications of Cysteines in VDAC3: Indication that VDAC3 may Signal the Mitochondrial Intermembrane Redox State Biophysical Journal 2016
Vito De Pinto
Simona Reina
Ankit Gupta
Angela Messina
Radhakrishnan Mahalakshmi
Role of cysteines in mammalian VDAC isoforms' function. Biochim. Biophys. Acta (Bioenergetics) 2016
Kamlesh Madhusudan Makwana
Radhakrishnan Mahalakshmi
Capping beta-Hairpin with N-terminal D-Amino Acid Stabilizes Peptide Scaffold. Biopolymers 2016
Ankit Gupta
Bharat Ramasubramanian Iyer
Deepti Chaturvedi
Svetlana Rajkumar Maurya
Radhakrishnan Mahalakshmi
Thermodynamic, structural and functional properties of membrane protein inclusion bodies are analogous to purified counterparts: Case study from bacteria and humans. RSC Advances 2015
Kamlesh Makwana
Radhakrishnan Mahalakshmi
Nature of aryl-tyrosine interactions contribute to beta-hairpin scaffold stability: NMR evidence for alternate ring geometry. Phys. Chem. Chem. Phys. 2015
Radhakrishnan Mahalakshmi
Folding and stability of transmembrane beta-barrels of bacterial and human origin: Probing underlying similarities and principal differences using in vitro systems. Proc. Indian Natn. Sci. Acad. 2015
Kamlesh Madhusudan Makwana
Radhakrishnan Mahalakshmi
NMR Analysis of Tuning Cross-Strand Phe/Tyr/Trp - Trp Interactions in Designed beta-Hairpin Peptides: Terminal Switch from L- to D-Amino Acid as a Strategy for beta-Hairpin Capping. J. Phys. Chem. B 2015
Kamlesh Madhusudan Makwana
Radhakrishnan Mahalakshmi
Trp-Trp Cross-Linking: A Structure-Reactivity Relationship in the Formation and Design of Hyperstable Peptide beta-Hairpin and alpha-Helix Scaffolds. Organic Letters 2015
Kamlesh Madhusudan Makwana
Radhakrishnan Mahalakshmi
Structure Stabilizing Role of Aromatic Interactions is Decided by Spatial Arrangement of Aromatic Pairs: A Case Study With Designed Peptide beta-Hairpins. Peptides 2015
Bharat Ramasubramanian Iyer
Radhakrishnan Mahalakshmi
Residue-dependent thermodynamic cost and barrel plasticity balances activity in the PhoPQ-activated enzyme PagP of Salmonella typhimurium Biochemistry 2015
Kamlesh Madhusudan Makwana
Radhakrishnan Mahalakshmi
Implications of Aromatic-Aromatic Interactions: From Protein Structures to Peptide Models. Protein Science 2015
Svetlana Rajkumar Maurya
Radhakrishnan Mahalakshmi
N-helix and cysteines inter-regulate human mitochondrial VDAC-2 function and biochemistry. Journal of Biological Chemistry 2015
Svetlana Rajkumar Maurya
Radhakrishnan Mahalakshmi
Influence of Protein - Micelle Ratios and Cysteine Residues on the Kinetic Stability and Unfolding Rates of Human Mitochondrial VDAC-2 PLoS One 2014
Kamlesh Madhusudan Makwana
Radhakrishnan Mahalakshmi
Comparative analysis of cross strand aromatic-Phe interactions in designed peptide beta-hairpins. Organic & Biomolecular Chemistry 2014
Svetlana Rajkumar Maurya
Radhakrishnan Mahalakshmi
Cysteine Residues Impact the Stability and Micelle Interaction Dynamics of the Human Mitochondrial beta-barrel Anion Channel hVDAC-2. PLoS One 2014
Ravikiran Boddepalli
Radhakrishnan Mahalakshmi
Unusual post-translational protein modifications : The benefits of sophistication. RSC Advances 2014
Ankit Gupta
Punit Zadafiya
Radhakrishnan Mahalakshmi
Differential Contribution of Tryptophans to the Folding and Stability of the Attachment Invasion Locus Transmembrane beta-Barrel from Yersinia pestis. Scientific Reports 2014
Kamlesh Madhusudan Makwana
Radhakrishnan Mahalakshmi
Asymmetric contribution of aromatic interactions stems from spatial positioning of the interacting aryl pairs in beta-hairpins ChemBioChem 2014
Deepti Chaturvedi
Radhakrishnan Mahalakshmi
Juxtamembrane tryptophans possess distinct roles in defining the OmpX barrel-micelle boundary and packing-facilitated protein-micelle association FEBS Lett. 2014
Svetlana Rajkumar Maurya
Deepti Chaturvedi
Radhakrishnan Mahalakshmi
Modulating lipid dynamics and membrane fluidity to drive rapid folding of a transmembrane barrel Scientific Reports 2013
Svetlana Rajkumar Maurya
Radhakrishnan Mahalakshmi
Modulation of human mitochondrial voltage-dependent anion channel 2 (hVDAC-2) structural stability by cysteine-assisted barrel-lipid interactions. Journal of Biological Chemistry 2013
Kamlesh Madhusudan Makwana
SR Raghothama
Radhakrishnan Mahalakshmi
Stabilizing effect of electrostatic vs aromatic interactions in diproline nucleated peptide beta-hairpins. Phys. Chem. Chem. Phys. 2013
Muralikrishna Lella
Radhakrishnan Mahalakshmi
Pro-Gly mediated conformational switch of Mycobacteriophage D29 holin transmembrane domain I is lipid concentration driven. Chemical Communications 2013
Deepti Chaturvedi
Radhakrishnan Mahalakshmi
Methionine Mutations of Outer Membrane Protein X Influence Structural Stability and beta-Barrel Unfolding. PLoS One 2013
Ankit Gupta
Deepti Chaturvedi
Radhakrishnan Mahalakshmi
Modified CNBr cleavage protocol for efficient separation of Met-Ser containing OmpX-Om14 membrane protein fusion Intl. Rev. Biophys. Chem. 2012

Group