Personal Details
- Name: Dr. Sanjeev Shukla
- Designation: Associate Professor
- Department: Biological Sciences
- E-Mail: sanjeevs[AT]iiserb.ac.in
- Phone: +91 755 269 1409
Academic Details
- Ph.D. (Nov 2003-Feb 2009): Advanced Centre for Treatment, Research and Education in Cancer (CRI-ACTREC), Navi Mumbai
Awards and Fellowships
- April 2017-present: Wellcome Trust/ DBT India Alliance Intermediate Fellow
Academic Details
- Associate Professor (April 2018- Present), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
- Assistant Professor (May 2013-March 2018): Biological Sciences, Indian Institute of Science, Education and Research (IISER) Bhopal
- Postdoctoral Fellow (March 2010-March 2013): National Cancer Institute, National Institutes of Health, Maryland, USA
- Postdoctoral Fellow (May 2009-Feb 2010): Georgetown University Medical Centre, Washington DC, USA
Interplay Between Epigenetic Changes And Alternative Pre-MRNA Splicing In Tumorigenesis
- Examination of DNA methylation mediated regulation of alternative splicing via modulation of reciprocal binding of CTCF and BORIS in cancer cells.
- Analysis of DNA binding proteins/ transcription factors and upstream pathways that are involved in regulation of alternative splicing
- Examination of role of cancer specific alternative spliced isoforms in tumorigenesis
| Authors | Title of Article | Journal | Year |
|---|---|---|---|
| Subhashis Natua Shruti Ganesh Dhamdhere Srinivas Abhishek Mutnuru Sanjeev Shukla |
Interplay within tumor microenvironment orchestrates neoplastic RNA metabolism and transcriptome diversity | WIREs RNA | 2021 |
| Cheemala Ashok Neha Ahuja Subhashis Natua Jharna Mishra Atul Samaiya Sanjeev Shukla |
E2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression | Oncogenesis | 2021 |
| Anchala Pandey Pooja Yadav Sanjeev Shukla |
Unfolding the role of autophagy in the cancer metabolism | Biochem. & Biophy. Reports | 2021 |
| Sandhya Yadav Deepak Pant Atul Samaiya Neetu Kalra Sanjay Gupta Sanjeev Shukla |
ERK1/2-EGR1-SRSF10 Axis Mediated Alternative Splicing Plays a Critical Role in Head and Neck Cancer | Frontiers in Cell and Developmental Biology | 2021 |
| Shubhashis Natua Ashok Cheemala Sanjeev Shukla |
Hypoxia-induced alternative splicing in human diseases: the pledge, the turn, and the prestige | Cell and Molecular Life Sciences | 2021 |
| Arpankumar Choksi Apoorva Parulekar Richa Pant Vibhuti Kumar Shah Ramakrishna Nimma Priyanka Firmal Smriti Singh Gopal C. Kundu Sanjeev Shukla Samit Chattopadhyay |
Tumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1 | BMC Cancer & Metabolism | 2021 |
| Madhura R Pandkar Shruti G Dhamdhere Sanjeev Shukla |
Oxygen gradient and tumor heterogeneity: The chronicle of a toxic relationship | BBA Reviews on Cancer | 2021 |
| Neha Ahuja Cheemala Ashok Subhashis Natua Deepak Pant Anna Cherian Madhura R Pandkar Pooja Yadav Vishnu Narayanan SS Jharna Mishra Atul Samaiya Sanjeev Shukla |
Hypoxia-induced TGFb-RBFOX2-ESRP1 axis regulates human MENA alternative splicing and promotes EMT in breast cancer | NAR Cancer | 2020 |
| Deepak Pant Sathiya P Narayanan Nagarjun Vijay Sanjeev Shukla |
Hypoxia-induced changes in intragenic DNA methylation correlate with alternative splicing in breast cancer | Journal of Biosciences | 2020 |
| S R Adusumalli D G Rawale K Thakur L Purushottam N C Reddy N Kalra S Shukla V Rai |
Chemoselective and Site‐Selective Lysine‐Directed Lysine Modification Enables Single‐Site Labeling of Native Proteins | Angewandte Chemie International Edition | 2020 |
| Amit Gupta Sandhya Yadav Archana P T Jharna Mishra Atul Samaiya Sanjeev Shukla |
HNRNP2B1-MST1R-AKT axis contributes to the EMT in head and neck cancer | Nature Laboratory Investigation | 2020 |
| Sandhya Yadav Somnath D. Bhagat Amit Gupta Atul Samaiya Aasheesh Srivastava Sanjeev Shukla |
Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer | BMC Cancer | 2019 |
| M Chilamari N Kalra S Shukla Rai Vishal |
Single-site labeling of lysine in proteins through a metal-free multicomponent approach | Chemical Communications | 2018 |
| S R Adusumalli D G Rawale U Singh P Tripathi R Paul N Kalra R K Mishra S Shukla V Rai |
Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology | J.Am.Chem.Soc | 2018 |
| Amit Gupta Athira Ajith Smriti Singh Rajendra Kumar Panday Atul Samaiya Sanjeev Shukla |
PAK2–c-Myc–PKM2 axis plays an essential role in head and neck oncogenesis via regulating Warburg effect | Cell Death and Disease | 2018 |
| Sathiya Pandi Narayanan Smriti Singh Sanjeev Shukla |
A saga of cancer epigenetics: linking epigenetics to alternative splicing | Biochemical J | 2017 |
| Smriti Singh Sathiya Pandi Narayanan Kajal Biswas Amit Gupta Neha Ahuja Sandhya Yadav Rajendra Kumar Panday Atul Samaiya Shyam K Sharan Sanjeev Shukla |
Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect | Proceedings of the National Academy of Sciences | 2017 |
| Ryan J Marina David Sturgill Marc A Bailly Morgan Thenoz Garima Verma Maria F Prigge Kyster K Nanan Sanjeev Shukla Nazmul Haque Shalini Oberdoerffer |
TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing | EMBO J | 2016 |
| Sathiya Pandi Narayanan Smriti Singh Amit Gupta Sandhya Yadav Shree Ram Singh Sanjeev Shukla |
Integrated genomic analyses identify KDM1A’s role in cell proliferation via modulating E2F signaling activity and associate with poor clinical outcome in oral cancer | Cancer Letters | 2015 |
Open Positions
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I am looking for postdoctoral candidate who is interested to study epigenetic regulation of alternative pre-mRNA splicing/RNA processing in tumorigenesis. Interested candidate can send their cv and statement of research interest by email to me at sanjeevs@iiserb.ac.in
Epigibility: Candidate should have PhD in biological sciences from recognized university/institution.
Desirable: Prior experience with molecular biology techniques. Candidates with experience in analysis of next-generation sequencing data/ RNA work / chromatin biology are encouraged to apply.
PhD Students
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Smriti Singh
smritis@iiserb.ac.in
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Amit Gupta
gamit@iiserb.ac.in
-
Sandhya Yadav
syadav@iiserb.ac.in
-
Neha Ahuja
nehavs2@iiserb.ac.in