Department of Biological Sciences
Indian Institute of Science Education and Research Bhopal


Personal Details


  • Name: Prof. Sanjeev Shukla
  • Designation: Professor
  • Department: Biological Sciences
  • E-Mail: sanjeevs@iiserb.ac.in
  • Phone: +91 755 269 1409


Academic Details


  • Professor (October 2023- Present), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
  • Associate Professor (April 2018- September 2023), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
  • Assistant Professor (May 2013-March 2018): Biological Sciences, Indian Institute of Science, Education and Research (IISER) Bhopal .
  • Postdoctoral Fellow (March 2010-March 2013): National Cancer Institute, National Institutes of Health, Maryland, USA.
  • Postdoctoral Fellow (May 2009-Feb 2010): Georgetown University Medical Centre, Washington DC, USA.
  • Ph.D. (Nov 2003-Feb 2009): Advanced Centre for Treatment, Research and Education in Cancer (CRI-ACTREC), Navi Mumbai

Awards and Fellowships


  • December 2020, SERB STAR April 2017-March 2023: Wellcome Trust/ DBT India Alliance Intermediate Fellow
  • April 2017 Wellcome Trust/ DBT India Alliance Intermediate Fellow

Interplay Between Epigenetic Changes And Alternative Pre-MRNA Splicing In Tumorigenesis


  • Examination of DNA methylation mediated regulation of alternative splicing via modulation of reciprocal binding of CTCF and BORIS in cancer cells.
  • Analysis of DNA binding proteins/ transcription factors and upstream pathways that are involved in regulation of alternative splicing
  • Examination of role of cancer specific alternative spliced isoforms in tumorigenesis
Authors Title of Article Journal Year
Palma FR
Gantner BN
Sakiyama MJ
Kayzuka C
Shukla S
Lacchini R
Cunniff B
Bonini MG
ROS production by mitochondria: function or dysfunction? Oncogene 2024
Yadav P
Pandey A
Kakani P
Mutnuru A S
Samaiya A
Mishra J
Shukla S
Hypoxia-induced loss of SRSF2-dependent DNA methylation promotes CTCF-mediated alternative splicing of VEGFA in breast cancer iScience 2023
Madhura R Pandkar
Adarsh Raveendran
Kajal Biswas
Srinivas Abhishek Mutnuru
Jharna Mishra
Atul Samaiya
Tyler Malys
Alexander Y Mitrophanov
Shyam K Sharan
Sanjeev Shukla
PKM2 dictates the poised chromatin state of PFKFB3 promoter to enhance breast cancer progression NAR Cancer 2023
Madhura R Pandkar
Sommya Sinha
Atul Samaiya
Sanjeev Shukla
Oncometabolite lactate enhances breast cancer progression by orchestrating histone lactylation-dependent c-Myc expression Translational Oncology 2023
Mishra T
Bhardwaj V
Ahuja N
Gadgil P
Ramdas P
Shukla S
Chande A
Improved loss-of-function CRISPR/Cas9 genome editing in human cells concomitant with inhibition of TGF? signaling. Molecular Therapy - Nucleic Acids 2022
Mishra T
Dalavi R
Joshi G
Kumar A
Pandey P
Shukla S
Mishra K R
Chande A
The role of SARS CoV-2 spike NTD mutations in determining neutralization susceptibility and virion infectivity Life Science Alliance 2022
Reddy C N
Molla R
Joshi N P
Sajeev K T
Basu I
Kawadkar J
Kalra N
Mishra K R
Chakrabarty S
Shukla S
Rai V
Traceless cysteine-linchpin enables precision engineering of lysine in native proteins Nature Communications ( Open Access from 2016) 2022
Thakur K
Sajeev K T
Singh K S
Ragendu V
Rawale G D
Adusumalli R S
Kalra N
Shukla S
Mishra K R
Rai V
Human Behavior-Inspired Linchpin-Directed Catalysis for Traceless Precision Labeling of Lysine in Native Proteins Bioconjugate Chemistry 2022
Subhashis Natua
Shruti Ganesh Dhamdhere
Srinivas Abhishek Mutnuru
Sanjeev Shukla
Interplay within tumor microenvironment orchestrates neoplastic RNA metabolism and transcriptome diversity WIREs RNA 2021
Cheemala Ashok
Neha Ahuja
Subhashis Natua
Jharna Mishra
Atul Samaiya
Sanjeev Shukla
E2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression Oncogenesis 2021
Anchala Pandey
Pooja Yadav
Sanjeev Shukla
Unfolding the role of autophagy in the cancer metabolism Biochem. & Biophy. Reports 2021
Sandhya Yadav
Deepak Pant
Atul Samaiya
Neetu Kalra
Sanjay Gupta
Sanjeev Shukla
ERK1/2-EGR1-SRSF10 Axis Mediated Alternative Splicing Plays a Critical Role in Head and Neck Cancer Frontiers in Cell and Developmental Biology 2021
Shubhashis Natua
Ashok Cheemala
Sanjeev Shukla
Hypoxia-induced alternative splicing in human diseases: the pledge, the turn, and the prestige Cell and Molecular Life Sciences 2021
Arpankumar Choksi
Apoorva Parulekar
Richa Pant
Vibhuti Kumar Shah
Ramakrishna Nimma
Priyanka Firmal
Smriti Singh
Gopal C. Kundu
Sanjeev Shukla
Samit Chattopadhyay
Tumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1 BMC Cancer & Metabolism 2021
Madhura R Pandkar
Shruti G Dhamdhere
Sanjeev Shukla
Oxygen gradient and tumor heterogeneity: The chronicle of a toxic relationship BBA Reviews on Cancer 2021
Neha Ahuja
Cheemala Ashok
Subhashis Natua
Deepak Pant
Anna Cherian
Madhura R Pandkar
Pooja Yadav
Vishnu Narayanan SS
Jharna Mishra
Atul Samaiya
Sanjeev Shukla
Hypoxia-induced TGFb-RBFOX2-ESRP1 axis regulates human MENA alternative splicing and promotes EMT in breast cancer NAR Cancer 2020
Deepak Pant
Sathiya P Narayanan
Nagarjun Vijay
Sanjeev Shukla
Hypoxia-induced changes in intragenic DNA methylation correlate with alternative splicing in breast cancer Journal of Biosciences 2020
S R Adusumalli
D G Rawale
K Thakur
L Purushottam
N C Reddy
N Kalra
S Shukla
V Rai
Chemoselective and Site‐Selective Lysine‐Directed Lysine Modification Enables Single‐Site Labeling of Native Proteins Angewandte Chemie International Edition 2020
Amit Gupta
Sandhya Yadav
Archana P T
Jharna Mishra
Atul Samaiya
Sanjeev Shukla
HNRNP2B1-MST1R-AKT axis contributes to the EMT in head and neck cancer Nature Laboratory Investigation 2020
Sandhya Yadav
Somnath D. Bhagat
Amit Gupta
Atul Samaiya
Aasheesh Srivastava
Sanjeev Shukla
Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer BMC Cancer 2019
M Chilamari
N Kalra
S Shukla
Rai Vishal
Single-site labeling of lysine in proteins through a metal-free multicomponent approach Chemical Communications 2018
S R Adusumalli
D G Rawale
U Singh
P Tripathi
R Paul
N Kalra
R K Mishra
S Shukla
V Rai
Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology J.Am.Chem.Soc 2018
Amit Gupta
Athira Ajith
Smriti Singh
Rajendra Kumar Panday
Atul Samaiya
Sanjeev Shukla
PAK2–c-Myc–PKM2 axis plays an essential role in head and neck oncogenesis via regulating Warburg effect Cell Death and Disease 2018
Sathiya Pandi Narayanan
Smriti Singh
Sanjeev Shukla
A saga of cancer epigenetics: linking epigenetics to alternative splicing Biochemical J 2017
Smriti Singh
Sathiya Pandi Narayanan
Kajal Biswas
Amit Gupta
Neha Ahuja
Sandhya Yadav
Rajendra Kumar Panday
Atul Samaiya
Shyam K Sharan
Sanjeev Shukla
Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect Proceedings of the National Academy of Sciences 2017
Ryan J Marina
David Sturgill
Marc A Bailly
Morgan Thenoz
Garima Verma
Maria F Prigge
Kyster K Nanan
Sanjeev Shukla
Nazmul Haque
Shalini Oberdoerffer
TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing EMBO J 2016
Sathiya Pandi Narayanan
Smriti Singh
Amit Gupta
Sandhya Yadav
Shree Ram Singh
Sanjeev Shukla
Integrated genomic analyses identify KDM1A’s role in cell proliferation via modulating E2F signaling activity and associate with poor clinical outcome in oral cancer Cancer Letters 2015
Sanjeev Shukla
E Kavak
M Gregory
M Imashimizu
B Shutinoski
M Kashlev
P Oberdoerffer
R Sandberg
S Oberdoerffer
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing Nature ( Through e-Shodh Sindhu) 2011

Book Chapters

Author Editors Title Publisher Year
Madhura R Pandkar
Pooja Yadav
Sanjeev Shukla


Epigenetic modifications and alternative pre-mRNA splicing in cancer Elsevier 2023
Deepak Pant
Srinivas Abhishek Mutnuru
Sanjeev Shukla


Epigenetic regulation during hypoxia and its implication in cancer Springer 2022

Open Positions


  • I am looking for postdoctoral candidate who is interested to study epigenetic regulation of alternative pre-mRNA splicing/RNA processing in tumorigenesis. Interested candidate can send their cv and statement of research interest by email to me at sanjeevs@iiserb.ac.in

    Epigibility: Candidate should have PhD in biological sciences from recognized university/institution.

    Desirable: Prior experience with molecular biology techniques. Candidates with experience in analysis of next-generation sequencing data/ RNA work / chromatin biology are encouraged to apply.

PhD Students


  • Smriti Singh
    smritis@iiserb.ac.in
  • Amit Gupta
    gamit@iiserb.ac.in
  • Sandhya Yadav
    syadav@iiserb.ac.in
  • Neha Ahuja
    nehavs2@iiserb.ac.in