Prof himanshu kumar

Professor
hkumar@iiserb.ac.in
Phone: +91 755 269 1413
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Profile Details

Associate Professor (August 2016-till date), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
Assistant Professor (July 2010-July 2016), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
Adjunct Associate Professor. (March 2010-till date),World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan.
Associate/ Section Editor (May 2012 - till date), International Reviews of Immunology, Informa Healthcare press.
JSPS Post-doctoral Fellow (April 2008-March 2010), Laboratory of Host Defense, World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan.
Ph.D.[April 2004-March 2008 as Japanese Government Fellow (MEXT Fellow)], Immunobiology, Graduate School of Medicine, Osaka University, Japan with Professor. Shizuo Akira.
Awarded Ramanujan Fellowship from Department of Science and Technology, Government of India (July 2010-).
Awarded Kishimoto Foundation Fellowship from WPI Immunology Frontier Research Center, Osaka University (April 2010-June 2010).
Awarded Japan Society for the Promotion of Science (JSPS) Post-doctoral Fellowship from Government of Japan (April 2008-March 2010).
Awarded Japanese Government Scholarship (MEXT) from Government of Japan (April 2003-March 2008) for pursuing doctoral thesis.
Innate immunity is first line of defense system and promptly activated after microbial infection to initiate protective responses through production of inflammatory cytokines from various immune cells. Innate immune system consists of humoral components such as complements, acute phase proteins and cellular components such as Monocytes, Macrophages, Dendritic cells, Eosinophils, Basophils, Neutrophils, Mast cells and Natural-killer cells. The humoral components have a broad range of actions against microorganisms, including gram-positive and gram-negative bacteria, fungi and viruses. The cellular components either directly kill the microbial pathogens through phagocytosis or induce production of cytokines, which helps in the elimination of pathogens. The innate immune cells express various pattern recognition receptors (PRRs) which recognize signature molecules of the pathogen. These signature molecules are essential for the survival of the pathogen and known as a pathogen associated molecular pattern (PAMPs). These PRRs recognizes different PAMPs of the pathogen in various compartments of the cells and trigger induction of inflammatory cytokines for the host defense. Furthermore, the innate immune responses are also required for the development of the pathogen specific adaptive immunity through B and T lymphocytes.



The aims of our group are: To identify new innate receptors or adaptor or signaling molecules through various screening systems and characterize the identified genes in vitro and in vivo.
To integrate the basic knowledge of innate immune signaling pathways to the susceptibility with human infectious disease.
To study the cross-talk and diverse regulation of various innate signaling pathways.
To integrate the basic knowledge of PAMPs, PRRs and innate immune signaling pathways in development of ideal vaccine adjuvant.
SNo Authors Title of Article Pid Journal Year
1 Pandikannan Krishnamoorthy, Athira S. Raj ,Himanshu Kumar Identification of gene classifier and modules associated with SARS-CoV-2 ARI in nasal swab 5455 Genes & Diseases 2024
2 Riya Chaudhary,Aparna Meher,Pandikannan Krishnamoorthy,Himanshu Kumar Interplay of host and viral factors in inflammatory pathway mediated cytokine storm during RNA virus infection 5457 Current Research in Immunology 2023
3 Athira S Raj,Pandikannan Krishnamoorthy,Himanshu Kumar Machine learning-driven blood transcriptome-based discovery of SARS-CoV-2 specific severity biomarkers 4331 Journal of Medical Virology 2023
4 Nilanjana Das,Pramod Kumar,Athira S Raj,Pandikannan Krishnamoorthy,Himanshu Kumar Host and viral non-coding RNAs in dengue pathogenesis 3849 Reviews in Medical Virology 2022
5 Himanshu Kumar,Puja Kumari Dimensions of inflammation in host defense and diseases 3887 International Reviews of Immunology 2022
6 Himanshu Kumar How metabolism and metabolites shape immunity during disease 3889 International Reviews of Immunology 2022
7 Akhilesh Kumar,Shalabh Mishra,Ashish Kumar,Ashwin Ashok Raut,Seiichi Sato,Akinori Takaoka ,Himanshu Kumar Essential role of Rnd1 in innate immunity during viral and bacterial infections 3891 Cell Death and Disease 2022
8 Himanshu Kumar Fatal ReincaRNAtion of VIRUS causing COronaVIrus disease 5467 International Reviews of Immunology 2022
9 Dipayan Rudra,Himanshu Kumar Advances and challenges in CAR-T cell-mediated immunotherapy 5469 International Reviews of Immunology 2022
10 Himanshu Kumar,Puja Kumari,Ashwathi Rajeevan,Akhilesh Kumar,Athira S Raj,Shalabh Mishra Innate Immune Sensing of Influenza A Viral RNA Through IFI16 Promotes Pyroptotic Cell Death 3545 iScience 2022
11 Himanshu Kumar Components of specific immunity in host defense 3881 International Reviews of Immunology 2021
12 Himanshu Kumar Cancer and Immunity: who is shaping whom? 3883 International Reviews of Immunology 2021
13 Himanshu Kumar Immune-mediated organ pathologies of vital organs 3885 International Reviews of Immunology 2021
14 Pandikannan Krishnamoorthy ,Athira S. Raj ,Swagnik Roy ,Nachimuthu Senthil Kumar ,Himanshu Kumar Comparative transcriptome analysis of SARS-CoV, MERS-CoV, and SARS-CoV-2 to identify potential pathways for drug repurposing 2647 Computers in Biology and Medicine 2021
15 Ranjeet Singh Mahla,Akhilesh Kumar ,Helena J Tutill,Sreevidhya Tarakkad Krishnaji ,Bharathwaj Sathyamoorthy ,Mahdad Noursadeghi ,Judith Breuer ,Amit Kumar Pandey ,Himanshu Kumar NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial infection 2649 Tuberculosis 2021
16 Richa Mishra,Pandikannan Krishnamoorthy ,Himanshu Kumar MicroRNA-30e-5p Regulates SOCS1 and SOCS3 During Bacterial Infection 2651 Frontiers in Cellular and Infection Microbiology 2021
17 Annesa Das,Kuldeep Singh Chauhan,Himanshu Kumar,Prafullakumar Tailor Mutation in Irf8 Gene (Irf8R294C) Impairs Type I IFN-Mediated Antiviral Immune Response by Murine pDCs 3523 Frontiers in Immunology 2021
18 Himanshu Kumar Immune-mediated organ pathologies of vital organs 3527 International Reviews of Immunology 2021
19 Himanshu Kumar Cancer and immunity: who is shaping whom? 3529 International Reviews of Immunology 2021
20 Himanshu Kumar Components of specific immunity in host defense 3531 International Reviews of Immunology 2021
21 Himanshu Kumar Sentinels of innate immunity in disease pathogenesis and development of therapeutics 3533 International Reviews of Immunology 2021
22 Akhilesh Kumar,Nilanjana Das,Himanshu Kumar COVert IDentities of current worldwide pandemic 3537 International Reviews of Immunology 2021
23 Irene Saha,Hemant Jaiswal,Richa Mishra,Hendrick J Nel,Jaring Scheuder,Monika Kaushik,Kuldeep Singh Chauhan,Bhupendra Singh Rawat,Renjeny THomas,Shalin Naik,Himanshu Kumar,Prafullakumar Tailor RelB suppresses type I Interferon signaling in dendritic cells 2087 Cellular Immunology 2020
24 Himanshu Kumar Balancing immune tolerance and immune responses 2089 International Reviews of Immunology 2020
25 Himanshu kumar Therapeutic approaches for genetic and infectious diseases 2091 International Reviews of Immunology 2020
26 Richa Mishra,Sanjana Bhattacharya,Bhupendra Singh Rawat,Ashish Kumar,Akhilesh Kumar,Kavita Niraj,Ajit Chande ,Puneet Gandhi,Dheeraj Khetan,Amita Aggarwal ,Seiichi Sato,Prafullakumar Tailor,Akinori Takaoka,Himanshu Kumar MicroRNA-30e-5p has an Integrated Role in the Regulation of the Innate Immune Response during Virus Infection and Systemic Lupus Erythematosus 2641 iScience 2020
27 Richa Mishra,Pandikannan Krishnamoorthy ,S.Gangamma , Ashwin Ashok Raut ,Himanshu Kumar Particulate matter (PM10) enhances RNA virus infection through modulation of innate immune responses 2643 Environmental Pollution 2020
28 Himanshu Kumar,Harshad Ingle,Ashish Kumar,Richa Mishra The Interplay Between Viral-Derived miRNAs and Host Immunity During Infection 2267 Frontiers in Immunology 2020
29 Himanshu Kumar Approaches for deciphering the molecular basis of disease and its translational benefits 1875 International Reviews of Immunology 2019
30 Himanshu Kumar,Akhilesh Kumar Long noncoding RNA: TRIMming the viral load 1647 Cellular & molecular Immunology 2019
31 Himanshu Kumar Immunity and its role in white plague and obesity 1649 International Reviews of Immunology 2019
32 Himanshu Kumar,Amit Awasthi T cell subtypes and its therapeutic potential in autoimmune diseases and cancer 1653 International Reviews of Immunology 2019
33 Himanshu Kumar,MIhai Oltean Donor-specific antibodies and organ transplantation: a dangerous mix 1739 International Reviews of Immunology 2019
34 Himanshu Kumar Host defense: basic, disease and translational biology 1741 International Reviews of Immunology 2019
35 Ashish Kumar,Akhilesh Kumar,Harshad Ingle,Sushil Kumar,Richa Mishra,Mahendra Kumar Verma,Debasis Biswas,Nachimuthu Senthil Kumar,Anamika Mishra,Ashwin Askok Raut,Akinori Takaoka,Himanshu Kumar MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2 1338 Journal of Virology 2018
36 Debajyoti Sinha,Akhilesh Kumar,Himanshu Kumar,Sanghamitra Bandyopadhyay,Debarka Sengupta dropClust: efficient clustering of ultra-large scRNA-seq data 1339 Nucleic Acids Research 2018
37 Himanshu Kumar Evolution of innate immune sensors and responses during immune disorders and immunization against microbial infection 1340 International Reviews of Immunology 2018
38 Himanshu Kumar,Adrian Bot Role of immune cells, immune modulating factors and immunotoxins in cancer immunotherapy 919 International Reviews of Immunology 2017
39 Himanshu Kumar,Adrian Bot Role of MicroRNAs in shaping innate immunity and as therapeutic targets for autoimmune diseases 920 International Reviews of Immunology 2017
40 Himanshu Kumar,Adrian Bot Innate immunity and infectious diseases–An update 711 International Reviews of Immunology 2017
41 Himanshu Kumar,Adrian Bot Antibodies in pathogenesis and management of diseases 712 International Reviews of Immunology 2017
42 Puja Kumari,Himanshu Kumar Viral Deubiquitinases: Role in Evasion of Anti-viral Innate Immunity 999 Critical Reviews in Microbiology 2017
43 Shalabh Mishra,Himanshu Kumar Balancing Anti-viral innate immunity and immune homeostasis 1000 Cellular & molecular Immunology 2017
44 Puja Kumari,Irene Saha,Athira Narayanan,Sathish Narayanan,Akinori Takaoka,Nachimuthu Senthil Kumar,Prafullakumar Tailor,Himanshu Kumar Essential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways 1001 Cell Death and Disease 2017
45 Mohan Reddy Bodireddy,Ranjeet Singh Mahla,P Md Khaja Mohinuddin,G Trivikram Reddy,D Vijaya Raghav Prasad,Himanshu Kumar Discovery of a new class of 16-membered (2Z, 11Z)-3, 11-di (aryl/naphthyl)-1, 13-dioxa-5, 9-dithia-2, 12-diazacyclohexadeca-2, 11-dienes as anti-tumor agents 708 RSC Advances 2016
46 Diwakar D Kulkarni,Himanshu Kumar,Pradip N Gandhale,Periyasamy Vijakumar,Anamika Mishra,Pradip B Ranaware,Ashwin Ashok Raut Genome Wide Host Gene Expression Analysis in Chicken Lungs Infected with Avian Influenza Viruses 709 PLoS One 2016
47 Mohammed Fawaz,Periyasamy Vijaykumar,Anamika Mishra,Pradip N Gandhale,Rupam Dutta,Nitin M Kamble,Shashi B Sudhakar,Parimal Roychoudhary,Himanshu Kumar,Diwakar D Kulkarni,Ashwin Ashok Raut Duck gut viral metagenome analysis captures snapshot of viral diversity. 710 BMC Genomics 2016
48 Puja Kumari,Sathish Narayanan,Himanshu Kumar Herpesviruses: interfering innate immunity by targeting viral sensing and interferon pathways 433 Reviews in Medical Virology 2015
49 Himanshu Kumar,Ashwin Ashok Raut,Akinori Takaoka,Shizuo Akira,Taro Kawai,Ashish Kumar,Ranjeet Singh Mahla,Shalabh Mishra,Harshad Ingle,Sushil Kumar IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependnt and independent anticancer activity 434 Cell Death and Disease 2015
50 Anamika MIshra,Ashwin Ashok Raut,Sushil Kumar,Harshad Ingle,Diwakar Dattatraya Kulkarni,Takeshi Kameyama,Akinori Takaoka,Shizuo Akira,Himanshu Kumar The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication 435 Science Signaling 2015
51 Raunaq Singh Nagi,Ashish Shekhar Bhat,Himanshu Kumar Cancer: a tale of aberrant PRR response 431 Frontiers in Immunology 2014
52 Deepak Bharti,Ashish Kumar,Ranjeet Singh Mahla,Sushil Kumar,Harshad Ingle,Hari Shankar,Beenu Joshi,Ashwin Ashok Raut,Himanshu Kumar The role of TLR9 polymorphism in susceptibility to pulmonary tuberculosis 432 Immunogenetics 2014
53 Ranjit Singh Mahla,Madhawa C Reddy,D. Vijaya Raghava Prasad,Himanshu Kumar Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology 428 Frontiers in Immunology 2013
54 Sushil Kumar,Harshad Ingle,DVR Prasad,Himanshu Kumar Recognition of Bacterial Infection by Innate Immune Sensors. Critical Reviews in Microbiology 429 Critical Reviews in Microbiology 2013
55 Himanshu Kumar,Adrian Bot Innate immune recognition mechanism and Translational Opportunities, an Editorial for special issue 430 International Reviews of Immunology 2013
56 Taro Kawai,Himanshu Kumar,Shizuo Akira Pathogen Recognition by the Innate Immune System 427 International Reviews of Immunology 2011