Prof raghuvir singh tomar

Professor
rst@iiserb.ac.in
Phone: +91 755 269 1411
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Profile Details

To identify the role of epigenetics in maintenance of cellular homeostatic pathways and stress:
In eukaryotes, DNA is organized in the form of chromatin which consists of repeating units called nucleosomes. The structure and function of chromatin is regulated by the specific enzymes that modify DNA and histone proteins to maintain cellular homeostatic mechanisms under a variety of pathophysiological conditions. Several classes of enzymes compete for binding to the chromatin. The coordination among chromatin modifying enzymes is critical for survival under various stress conditions. The imbalance in the activity of chromatin modifying enzymes leads to the development of disease pathologies. We trying to understand the significance of chromatin associated epigenetic changes in response to intra and extracellular factors. Following are our key research questions:
To dissect the role of yeast Cell Wall Integrity (CWI) pathway in flocculation of yeast.
To investigate the mechanism and significance of proteolytic clipping of histone proteins during development, aging, immunity and sepsis.
To study role of core histones, chromatin remodelling complexes in regulation of cellular homeostatic pathways, cell wall integrity and metal homeostasis.
To understand the mechanism of action of potential anti-cancer molecules.
SNo Authors Title of Article Pid Journal Year
1 Shraddha Chauhan,Raghuvir Singh Tomar Unveiling the molecular networks underlying cellular impairment in Saccharomyces cerevisiae: investigating the effects of magnesium oxide.............. 5383 Environmental Science and Pollution Research 2024
2 Ramesh Kumawat,Raghuvir Singh Tomar Dissecting the role of mitogen?activated protein kinase Hog1 in yeast flocculation 5399 FEBS Journal 2024
3 Raghuvir Singh Tomar,Nitu Saha Cdc73 majorly regulates apoptosis-inducing factor (AIF1) in Saccharomyces cerevisiae via the H3K36 methylation 5183 FEBS Letters 2024
4 Nitu Saha,Swati Swagatika,Raghuvir Singh Tomar Investigation of the acetic acid stress response in Saccharomyces cerevisiae with mutated H3 residues 4945 Microbial Cell 2023
5 Ramesh Kumawat,Raghuvir Singh Tomar Heavy metal exposure induces Yap1 and Hac1 mediated derepression of GSH1 and KAR2 by Tup1-Cyc8 complex 3605 Journal of Hazardous Materials 2022
6 Raghuvir Singh Tomar,Nitu Saha Copper inhibits protein maturation in the secretory pathway by targeting the Sec61 translocon in Saccharomyces cerevisiae 3945 Journal of Biological Chemistry 2022
7 Sakshi Singh,Rakesh Kumar Sahu,Anaswara Sugathan,Raghuvir Singh Tomar The H2A N-terminal tail is required to alleviate copper-induced stress in Saccharomyces cerevisiae 3603 FEMS Yeast Research 2021
8 Swati Swagatika,Raghuvir Singh Tomar Cantharidin downregulates PSD1 expression and inhibits autophagic flux in yeast cells 3115 FEBS Open Biol 2021
9 Pilendra Kumar Thakre,Rakesh Kumar Sahu,Raghuvir Singh Tomar Substitution of histone H3 arginine 72 to alanine leads to deregulation of isoleucine biosynthesis in budding yeast Saccharomyces cerevisiae 3117 Biochemistry and Cell Biology 2021
10 Rakesh Kumar Sahu,Sakshi Singh,Raghuvir Singh Tomar The ATP-dependent SWI/SNF and RSC chromatin remodelers cooperatively induce unfolded protein response genes during endoplasmic reticulum stress 3149 BBA-Gene Regulatory Mechanisms 2021
11 Raghuvir Singh Tomar,Rakesh Kumar Sahu,Sakshi Singh The N-Terminal Tail of Histone H3 Regulates Copper Homeostasis in Saccharomyces cerevisiae 2399 Molecular and Cellular Biology 2021
12 Swati Swagatika,Raghuvir Singh Tomar ABC transporter Pdr5 is required for cantharidin resistance in Saccharomyces cerevisiae 2545 Biochemical and Biophysical Research Communications 2021
13 Raghuvir Tomar,Sakshi Singh,Rakesh Sahu The mechanisms of action of chromatin remodelers and implications in development and diseases 2195 Biochemical Pharmacology 2020
14 Santhosh Sariki,Pushpendra Sahu,Laxmidhar Das,Nitu Saha,Rakesh Sahu,Raghuvir Tomar SWI/SNF chromatin remodeling complex contributes to clearance of cytoplasmic protein aggregates and regulates unfolded protein response in Saccharomyces cerevisiae 2007 FEBS Journal 2020
15 Pilendra Kumar Thakre,Upendarrao Golla,Ashis Biswas,Raghuvir Singh Tomar Identification of histone H3 and H4 amino acid residues important for the regulation of arsenite stress signaling in Saccharomyces cerevisiae 2041 Chemical Research in Toxicology 2020
16 Santhosh Kumar Sariki,Ramesh Kumawat,Vikash Singh,Raghuvir Singh Tomar Flocculation of Saccharomyces cerevisiae is dependent on activation of Slt2 and Rlm1 regulated by the Cell Wall Integrity pathway 1595 Molecular Microbiology 2019
17 Pushpendra Kumar Sahu,Sagar Salin,Sakshi Chauhan Reverse genetic analysis of yeast YPR099C/MRPL51 reveals a critical role of both overlapping ORFs in respiratory growth and MRPL51 in mitochondrial DNA maintenance 1597 FEMS Yeast Research 2019
18 Pushpendra Kumar Sahu,Raghuvir Singh Tomar The natural anticancer agent cantharidin alters GPI-anchored protein sorting by targeting Cdc1-mediated remodeling in endoplasmic reticulum 1368 Journal of Biological Chemistry 2019
19 Pushpendra Kumar Sahu,Sakshi Chauhan,Raghuvir Singh Tomar Crg1 N-terminus is essential for methyltransferase activity and Cantharidin resistance in Saccharomyces cerevisiae 1402 Biochemistry 2019
20 Pilendra Thakre,Athira SV,Upendarrao Golla,Sakshi Chauhan,Raghuvir Tomar Previously uncharacterized amino acid residues in histone H3 and H4 mutants with roles in DNA damage repair response and cellular aging 1337 FEBS Journal 2018
21 Gajendra Kumar Azad Modifying Chromatin by Histone Tail Clipping 1200 Journal of Molecular Biology 2018
22 Piyoosh Kumar Babele,Pilendra Kumar Thakre,Ramesh Kumawat,Raghuvir Singh Tomar Zinc oxide nanoparticles induce toxicity by affecting cell wall integrity pathway, mitochondrial function and lipid homeostasis in Saccharomyces cerevisiae 1226 Chemosphere 2018
23 Pilendra Singh Tomar,Bahadur Kumar Thakre,Biological Sciences SK,Raghuvir Patra A Pyridoindole-Based Multifunctional Bioprobe: pH-Induced Fluorescence Switching and Specific Targeting of Lipid Droplets 996 Chemistry -Asian Journal 2017
24 Raghuvir S Tomar,Sakshi Chauhan,Swati Swagatika,Upendarrao Golla A systematic assessment of chemical, genetic, and epigenetic factors influencing the activity of anticancer drug KP1019 (FFC14A) 998 Oncotarget 2017
25 Raghuvir Singh T,Mandal Papita,Sakshi Chauhan The biochemical analysis reveals multifactorial mechanism of histone H3 clipping by Chicken Liver Histone H3 protease 565 Biochemistry 2016
26 Gajendra Azad Partial purification of histone H3 proteolytic activity from budding yeast Saccharomyces cerevisiae 61 Yeast 2016
27 Sakshi Chauhan Efficient expression and purification of biologically active human cystatin proteins 65 Protein Expression and Purification 2016
28 Vikash ,Gajendra Kumar Azad,Upendarao Golla,Pushpendra Kumar Sahu,Santhosh Kumar Sariki,Raghuvir Singh T Sen1, the homolog of human Senataxin, is critical for survival through regulation of cellular redox homeostasis, mitochondrial function and TOR in Saccharomyces cerevisiae 620 FEBS Journal 2016
29 Upendarrao Golla,Deepthi Joseph,Raghvir Singh Tomar Combined Transcriptomics and Chemical-Genetics Reveal Molecular Mode of Action of Valproic acid, an Anticancer Molecule using Budding Yeast Model 634 Scientific Reports 2016
30 Gajendra Kumar Azad,Raghuvir Singh Tomar The multifunctional transcription factor Rap1: a regulator of yeast physiology 478 Frontiers Bioscience 2016
31 Raghuvir Singh Tomar,Amit Kumar Mondal,Amit Adhikary,Upendarrao Golla,Sanjit Konar Synthesis, structure, magnetic and biological activity studies of bis-hydrazone derived Cu(II) and Co(II) coordination compounds 479 Dalton Transactions 2016
32 Gajendra Kumar Azad,Vikash Singh,Shivani Barnawal,Mayur J Thakare,Raghuvir Singh Tomar The transcription factor Rap1p is required for tolerance to cell wall-perturbing agents and for cell wall maintenance in Saccharomyces cerevisiae 527 FEBS Lett. 2015
33 Vikash Singh,Gajendra Kumar Azad,Santhosh Kumar Sariki,Raghuvir Singh Tomar Flocculation in Saccharomyces cerevisiae is regulated by RNA/DNA helicase Sen1p 529 FEBS Lett. 2015
34 Raghuvir Singh Tomar,Bandi Goutham,Upendarrao Golla Molecular Cytotoxicity Mechanisms of the Herbicide Allyl Alcohol (Acrolein) in Budding Yeast 530 Chemical Research in Toxicology 2015
35 Gajendra Kumar Azad,Vikash Singh,Raghuvir Singh Tomar Assessment of the biological pathways targeted by isocyanate using N-succinimidyl N-methylcarbamate on budding yeast Saccharomyces cerevisiae. 522 PLoS One 2014
36 Shivani Baranwal,Amrendar M Reddy,Papita Mandal,Gajendra Kumar Azad,Vikash Singh,Raghuvir Singh Tomar Anti-cancer drug KP1019 induces Hog1 phosphorylation and protein ubiquitination in Saccharomyces cerevisiae 523 Eur J. Pharmacology 2014
37 Vikash Singh,Gajendra Kumar Azad,Papita Mandal,Amrendar M Reddy,Raghuvir Singh Tomar Anti-cancer drug KP1019 modulates epigenetics and induces DNA damage response in Saccharomyces cerevisiae 524 FEBS Lett. 2014
38 Shivani Barnawal,Gajendra Kumar Azad,Vikash Singh,Raghuvir Singh Tomar Signaling of chloroquine-induced stress in the yeast Saccharomyces cerevisiae requires the Hog1 and Slt2 MAPK Pathways 525 Antimicrobial Agents and Chemotherapy 2014
39 Papita Mandal,Sakshi Chauhan,Raghuvir Tomar H3 clipping activity of glutamate dehydrogenase is regulated by stefin B and chromatin structure 526 FEBS Journal 2014
40 Gajendra Kumar Azad,Vikash Singh,Mayur J Thakare,Shivani Barnawal,Raghuvir Singh Tomar Mitogen-activated protein kinase Hog1 is activated in response to curcumin exposure in the budding yeast Saccharomyces cerevisiae 528 BMC Microbiology 2014
41 Gajendra Kumar Azad,Vikash Singh,Papita Mandal,Prabhat Singh,Upendarrao Golla,Sakshi Chauhan,Shivani Barnawal,Raghuvir Singh Tomar Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target 531 FEBS Open Biol 2014
42 Papita Mandal,Naveen Verma,Gajendra Kumar Azad,Vikash Singh,Upendarrao Golla,Raghuvir Singh Tomar Epigenetics: Role of histone proteases in cellular functions and diseases. A book chapter in ‘Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health’. Maulik, N.; Karagiannis, T. (Eds.) 589 Springer press 2014
43 Gajendra Kumar Azad,Raghuvir Singh Tomar The emerging role of histone proteases in regulation of various biological processes 590 Molecular Biology Reports 2014
44 Gajendra Kumar Azad,Raghuvir Singh Tomar A comprehensive review illustrating the mode of action and biological pathways targeted by promising antioxidant drug, ebselen 591 Molecular Biology Reports 2014
45 Papita Mandal,Naveen Verma,Sakshi Chauhan,Raghuvir Singh Tomar Unexpected histone H3 tail clipping activity of Glutamate dehydrogenase 519 Journal of Biological Chemistry 2013
46 Upendarrao Golla,Vikash Singh,Gajendra Kumar Azad,Prabhat Singh,Papita Mandal,Raghuvir Singh Tomar Sen1p contributes to genomic integrity by regulating expression of Ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae 520 PLoS One 2013
47 Gajendra Kumar Azad,Vikash Singh,Upendarrao Golla,Raghuvir Singh Tomar Depletion of cellular iron by curcumin leads to alteration in histone acetylation and degradation of Sml1p in Saccharomyces cerevisiae. 521 PLoS One 2013
48 Papita Mandal,Gajendra Kumar Azad,Raghuvir Singh Tomar Identification of a novel histone H3 specific protease activity in nuclei of chicken liver 517 Biophysical and Biochemical Research Communication 2012
49 Gajendra Kumar Azad,Shah Jaimin Balkrishna,Narayanan Sathish,Sangit Kumar,Raghuvir Singh Tomar Multifunctional Ebselen drug functions through the activation of DNA damage response and alterations in nuclear proteins 518 Biochemical Pharmacology 2012