Dr varun chaudhary

Assistant Professor
varun.c@iiserb.ac.in
Phone: +91 755 269 1421
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Assistant Professor (June 2015 onwards): Indian Institute of Science, Education and Research (IISER) Bhopal
Postdoctoral Fellow (2010-2015): German Cancer Research Center Heidelberg Germany
PhD (2005- 2009): Dept. of Biomedical sciences, University of Sheffield.
Ramalingaswamy Fellowship by Department of Biotechnology (April 2017)
Functional analysis of Wnt signaling pathways in development, tissue patterning and diseases. Secreted Wnt proteins plays a pivotal role in development and progression of disease like colorectal cancer. Work done mainly in Drosophila melanogaster (Fruit fly) over last 3 decades has identified several well-conserved molecular players of the Wnt protein mediated signalling pathways, however we are still far from understanding the mechanisms by which these signalling pathways regulate tissue growth and patterning. Particularly their role in patterning polarized epithelial tissues remains unknown.

We are using the Drosophila model to understand the processes regulating epithelial patterning. We use combinations of cell and developmental biology tools to investigate how Wnt proteins are secreted and how they regulating patterning of epithelial tissue.
Understand mechanisms of Wnt protein secretion and signalling in polarized epithelium.
To solve the issue of how Wnt morphogens regulate tissue growth and patterning.
Investigate the relationship between Wnt signalling and intracellular vesicle trafficking.
SNo Authors Title of Article Pid Journal Year
1 Pranab Kumar Paul ,Shruti Umarvaish , Shivani Bajaj ,Rishana Farin S,Hrudya Mohan,Wim Annaert,Varun Chaudhary Maintenance of proteostasis by Drosophila Rer1 is essential for competitive cell survival and Myc-driven overgrowth 5289 PLOS Genetics 2024
2 Shefali Mehta,Swapnil Hingole,Varun Chaudhary The Emerging Mechanisms of Wnt Secretion and Signaling in Development 3409 Frontiers in Cell and Developmental Biology 2021
3 Anirban Das,Yogesh M. Gangarde,Viniti Tomar,Omkar Shinde,Tulsi Upadhyay,Sarfaraz Alam,Sudipta Ghosh,Varun Chaudhary,Ishu Saraogi Small-Molecule Inhibitor Prevents Insulin Fibrillogenesis and Preserves Activity 2863 Molecular Pharmaceutics 2020
4 Varun Chaudhary,Michael Boutros Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium 1863 PLOS Genetics 2019
5 Varun Chaudhary,Swapnil Hingole,Jana Frei,Fillip Port,David Strutt,Michael Boutros Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing 1703 Development 2019