Professor
maha@iiserb.ac.in
Phone:
+91 755 269 1423
Group Homepage
| SNo | Authors | Title of Article | Pid | Journal | Year |
|---|---|---|---|---|---|
| 1 | Anjana George,Roshika Ravi,Pankaj Tiwari,Shashank Srivastava,Vikas Jain,Radhakrishnan Mahalakshmi | Engineering a Hyperstable Yersinia pestis Outer Membrane Protein Ail Using Thermodynamic Design | 3661 | Journal of the American Chemical Society | 2022 |
| 2 | Altmash Khan,Gifty Kuriachan,Radhakrishnan Mahalakshmi | Cellular interactome of mitochondrial VDACs: Oligomerization and channel (mis)regulation. | 3659 | ACS Chemical Neuroscience | 2021 |
| 3 | Muralikrishna Lella,Radhakrishnan Mahalakshmi | De novo Design of Metal Binding Cleft in a Trp-Trp Stapled Thermostable ?-Hairpin Peptide | 3663 | Peptide Science | 2021 |
| 4 | Pankaj Tiwari,Radhakrishnan Mahalakshmi | Interplay of protein primary sequence, lipid membrane, and chaperone in ?-barrel assembly. | 2919 | Protein Science | 2021 |
| 5 | Pankaj Tiwari,Radhakrishnan Mahalakshmi | Molecular Assembly Pathway of Mitochondrial Sam50 in Native Membranes. | 2921 | Biophysical Journal | 2021 |
| 6 | Ankit Gupta,Radhakrishnan Mahalakshmi | Reversible folding energetics of Yersinia Ail barrel reveals a hyperfluorescent intermediate. | 2899 | Biochim. Biophys. Acta (Biomembranes) | 2020 |
| 7 | Bharat Iyer,Swadha Gupta,Henna Noordeen,Roshika Ravi,Meera Pawar,Anjana George,Radhakrishnan Mahalakshmi | Molecular Switch between Structural Compaction and Thermodynamic Stability by the Xxx?Pro Interface in Transmembrane ??Barrels | 2903 | Biochemistry | 2020 |
| 8 | Ankit Gupta,Radhakrishnan Mahalakshmi | Single-residue physicochemical characteristics kinetically partition membrane protein self-assembly and aggregation | 2905 | Journal of Biological Chemistry | 2020 |
| 9 | Radhakrishnan Mahalakshmi | Oxidative Thiol Modifications as Molecular Redox Sensors in Human Mitochondria | 2907 | Biophysical Journal | 2020 |
| 10 | William Rosencrans,M Martin-Queralt,Radhakrishnan Mahalakshmi,Sergey Bezrukov,Tatiana Rostovtseva | Dynamic Plasticity of Mitochondrial VDAC2 Revealed by Single-Molecule Electrophysiology. | 2909 | Biophysical Journal | 2020 |
| 11 | Shashank Srivastava,Radhakrishnan Mahalakshmi | Linking Folding Landscape with Function in the Human Mitochondrial VDAC2 | 2911 | Biophysical Journal | 2020 |
| 12 | Radhakrishnan Mahalakshmi | Do folding elements trade?off with function in the human mitochondrial metabolite transporter? | 2915 | FASEB Journal | 2020 |
| 13 | Shashank Srivastava,Radhakrishnan Mahalakshmi | Evolutionary selection of a 19-stranded mitochondrial ?-barrel scaffold bears structural and functional significance | 2917 | Journal of Biological Chemistry | 2020 |
| 14 | Radhakrishnan Mahalakshmi | Aromatic Interactions in β-Hairpin Scaffold Stability: A Historical Perspective. | 1325 | Arch. Biochem. Biophys | 2019 |
| 15 | Ankit Gupta,Radhakrishnan Mahalakshmi | Reversible folding energetics of Yersinia Ail barrel reveals a hyperfluorescent intermediate | 1841 | Biochim. Biophys. Acta (Biomembranes) | 2019 |
| 16 | Ankit Gupta,Radhakrishnan Mahalakshmi | Helix–strand interaction regulates stability and aggregation of the human mitochondrial membrane protein channel VDAC3 | 1461 | J. Gen. Physiol. | 2019 |
| 17 | Bharat Iyer,Radhakrishnan Mahalakshmi | Hydrophobic characteristic is energetically preferred for cysteine in a model membrane protein | 1462 | Biophysical Journal | 2019 |
| 18 | Radhakrishnan Mahalakshmi | Human Mitochondrial VDAC Functionality Governs Scaffold Stability. | 1288 | Biophysical Journal | 2018 |
| 19 | Shashank Ranjan Srivastava,Punit Zadafiya,Radhakrishnan Mahalakshmi | Hydrophobic mismatch modulates stability and plasticity of human mitochondrial VDAC2. | 1326 | Biophysical Journal | 2018 |
| 20 | Deepti Chaturvedi,Radhakrishnan Mahalakshmi | Folding determinants of transmembrane β-barrels using engineered OMP chimeras | 1149 | Biochemistry | 2018 |
| 21 | Muralikrishna Lella,Radhakrishnan Mahalakshmi | Direct Structural Annotation of Membrane Protein Aggregation Loci using Peptide–Based Reverse–Mapping | 1150 | J. Phys. Chem. Lett. | 2018 |
| 22 | Bharat Iyer,Pallavi Vetal,Henna Noordeen,Punit Zadafiya,Radhakrishnan Mahalakshmi | Salvaging the thermodynamic destabilization of interface histidine in transmembrane β-barrels | 1276 | Biochemistry | 2018 |
| 23 | Radhakrishnan Mahalakshmi,Deepti Chaturvedi | Position–specific contribution of interface tryptophans on membrane protein energetics | 1021 | Biochim. Biophys. Acta (Biomembranes) | 2018 |
| 24 | Radhakrishnan Mahalakshmi,Muralikrishna Lella | Solvation Driven Conformational Transitions in the Second Transmembrane Domain of Mycobacteriophage Holin. | 512 | Biopolymers | 2017 |
| 25 | Ankit Gupta,Bharat Ramasubramanian Iyer,Radhakrishnan Mahalakshmi | Approaches for preparation and biophysical characterization of transmembrane β-barrels | 514 | Springer Protocols Handbooks | 2017 |
| 26 | Muralikrishna Lella,Radhakrishnan Mahalakshmi | Metamorphic Proteins: Emergence of dual protein folds from one primary sequence. | 824 | Biochemistry | 2017 |
| 27 | Bharat Iyer,Punit Zadafiya,Pallavi Vetal,Radhakrishnan Mahalakshmi | Energetics of side chain partitioning of β-signal residues in unassisted folding of a transmembrane β-barrel protein. | 825 | Journal of Biological Chemistry | 2017 |
| 28 | Radhakrishnan Mahalakshmi,Svetlana Maurya | Mitochondrial VDAC2 and cell homeostasis: highlighting hidden structural features and unique functionalities. | 693 | Biological Reviews | 2017 |
| 29 | Radhakrishnan Mahalakshmi,Svetlana Maurya,Bhavna Burdak,Parini Surti,Manoj Patel,Vikas Jain | Structural plasticity of T4 transcription co-activator gp33 revealed by a protease-resistant unfolded state | 1019 | Biophysical and Biochemical Research Communication | 2017 |
| 30 | Deepti Chaturvedi,Radhakrishnan Mahalakshmi | Transmembrane β-barrels: Evolution, folding and energetics. | 1020 | Biochim. Biophys. Acta (Biomembranes) | 2017 |
| 31 | Muralikrishna Lella,Radhakrishnan Mahalakshmi | Engineering a Transmembrane Nanopore Ion Channel from a Membrane Breaker Peptide. | 513 | The Journal of Physical Chemistry Letters | 2016 |
| 32 | Svetlana Maurya,Radhakrishnan Mahalakshmi | Control of human VDAC-2 scaffold dynamics by interfacial tryptophans is position specific. | 694 | Biochim. Biophys. Acta (Biomembranes) | 2016 |
| 33 | Angela Anna Messina, Matteo Ceccarelli,Salvatore Foti,Andrea Magrì,Mariano Andrea Scorciapino,Francesca Guarino,Carlo Guardiani,Deepti Chaturvedi,Ankit Gupta,Rosaria Saletti,Vanessa Checchetto,Simona Reina,Radhakrishnan Mahalakshmi,Ildiko Szabo,Vito De Pinto | VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications. | 505 | Oncotarget | 2016 |
| 34 | Radhakrishnan Mahalakshmi,Svetlana Rajkumar Maurya | VDAC-2: Mitochondrial outer membrane regulator masquerading as a channel? | 506 | FEBS Journal | 2016 |
| 35 | Vikas Jain,Soumya Kamilla,Muralikrishna Lella,Radhakrishnan Mahalakshmi | Molecular Mechanism of Holin Transmembrane Domain I in Pore Formation and Bacterial Cell Death. | 507 | ACS Chemical Biology | 2016 |
| 36 | Radhakrishnan Mahalakshmi,Kamlesh Madhusudan Makwana | Stereopositional Outcome in the Packing of Dissimilar Aromatics in Designed beta-Hairpins | 508 | Chemistry - A European Journal | 2016 |
| 37 | Angela A. Messina,Matteo Ceccarelli, Salvatore Foti,Andrea Magrì,Mariano Andrea Scorciapino, Francesca Guarino,Carlo Guardiani,Deepti Chaturvedi,Ankit Gupta, Rosaria Saletti,Vanessa Checchetto,Simona Reina, Radhakrishnan Mahalakshmi,Ildiko Szabo, Vito De Pinto | Unexpected Modifications of Cysteines in VDAC3: Indication that VDAC3 may Signal the Mitochondrial Intermembrane Redox State | 509 | Biophysical Journal | 2016 |
| 38 | Radhakrishnan Mahalakshmi,Angela Messina,Ankit Gupta, Simona Reina,Vito De Pinto | Role of cysteines in mammalian VDAC isoforms' function. | 510 | Biochim. Biophys. Acta (Bioenergetics) | 2016 |
| 39 | Radhakrishnan Mahalakshmi,Kamlesh Madhusudan Makwana | Capping beta-Hairpin with N-terminal D-Amino Acid Stabilizes Peptide Scaffold. | 511 | Biopolymers | 2016 |
| 40 | Svetlana Rajkumar Maurya,Deepti Chaturvedi,Bharat Ramasubramanian Iyer,Ankit Gupta,Radhakrishnan Mahalakshmi | Thermodynamic, structural and functional properties of membrane protein inclusion bodies are analogous to purified counterparts: Case study from bacteria and humans. | 496 | RSC Advances | 2015 |
| 41 | Kamlesh Makwana,Radhakrishnan Mahalakshmi | Nature of aryl-tyrosine interactions contribute to beta-hairpin scaffold stability: NMR evidence for alternate ring geometry. | 497 | Phys. Chem. Chem. Phys. | 2015 |
| 42 | Radhakrishnan Mahalakshmi | Folding and stability of transmembrane beta-barrels of bacterial and human origin: Probing underlying similarities and principal differences using in vitro systems. | 498 | Proc. Indian Natn. Sci. Acad. | 2015 |
| 43 | Radhakrishnan Mahalakshmi,Kamlesh Madhusudan Makwana | NMR Analysis of Tuning Cross-Strand Phe/Tyr/Trp - Trp Interactions in Designed beta-Hairpin Peptides: Terminal Switch from L- to D-Amino Acid as a Strategy for beta-Hairpin Capping. | 499 | J. Phys. Chem. B | 2015 |
| 44 | Radhakrishnan Mahalakshmi,Kamlesh Madhusudan Makwana | Trp-Trp Cross-Linking: A Structure-Reactivity Relationship in the Formation and Design of Hyperstable Peptide beta-Hairpin and alpha-Helix Scaffolds. | 500 | Organic Letters | 2015 |
| 45 | Radhakrishnan Mahalakshmi,Kamlesh Madhusudan Makwana | Structure Stabilizing Role of Aromatic Interactions is Decided by Spatial Arrangement of Aromatic Pairs: A Case Study With Designed Peptide beta-Hairpins. | 501 | Peptides | 2015 |
| 46 | Bharat Ramasubramanian Iyer,Radhakrishnan Mahalakshmi | Residue-dependent thermodynamic cost and barrel plasticity balances activity in the PhoPQ-activated enzyme PagP of Salmonella typhimurium | 502 | Biochemistry | 2015 |
| 47 | Radhakrishnan Mahalakshmi,Kamlesh Madhusudan Makwana | Implications of Aromatic-Aromatic Interactions: From Protein Structures to Peptide Models. | 503 | Protein Science | 2015 |
| 48 | Radhakrishnan Mahalakshmi,Svetlana Rajkumar Maurya | N-helix and cysteines inter-regulate human mitochondrial VDAC-2 function and biochemistry. | 504 | Journal of Biological Chemistry | 2015 |
| 49 | Radhakrishnan Mahalakshmi,Svetlana Rajkumar Maurya | Influence of Protein - Micelle Ratios and Cysteine Residues on the Kinetic Stability and Unfolding Rates of Human Mitochondrial VDAC-2 | 489 | PLoS One | 2014 |
| 50 | Radhakrishnan Mahalakshmi,Kamlesh Madhusudan Makwana | Comparative analysis of cross strand aromatic-Phe interactions in designed peptide beta-hairpins. | 490 | Organic & Biomolecular Chemistry | 2014 |
| 51 | Radhakrishnan Mahalakshmi,Svetlana Rajkumar Maurya | Cysteine Residues Impact the Stability and Micelle Interaction Dynamics of the Human Mitochondrial beta-barrel Anion Channel hVDAC-2. | 491 | PLoS One | 2014 |
| 52 | Radhakrishnan Mahalakshmi,Ravikiran Boddepalli | Unusual post-translational protein modifications : The benefits of sophistication. | 492 | RSC Advances | 2014 |
| 53 | Radhakrishnan Mahalakshmi,Punit Zadafiya,Ankit Gupta | Differential Contribution of Tryptophans to the Folding and Stability of the Attachment Invasion Locus Transmembrane beta-Barrel from Yersinia pestis. | 493 | Scientific Reports | 2014 |
| 54 | Kamlesh Madhusudan Makwana,Radhakrishnan Mahalakshmi | Asymmetric contribution of aromatic interactions stems from spatial positioning of the interacting aryl pairs in beta-hairpins | 494 | ChemBioChem | 2014 |
| 55 | Radhakrishnan Mahalakshmi,Deepti Chaturvedi | Juxtamembrane tryptophans possess distinct roles in defining the OmpX barrel-micelle boundary and packing-facilitated protein-micelle association | 495 | FEBS Lett. | 2014 |
| 56 | Radhakrishnan Mahalakshmi,Deepti Chaturvedi,Svetlana Rajkumar Maurya | Modulating lipid dynamics and membrane fluidity to drive rapid folding of a transmembrane barrel | 484 | Scientific Reports | 2013 |
| 57 | Radhakrishnan Mahalakshmi,Svetlana Rajkumar Maurya | Modulation of human mitochondrial voltage-dependent anion channel 2 (hVDAC-2) structural stability by cysteine-assisted barrel-lipid interactions. | 485 | Journal of Biological Chemistry | 2013 |
| 58 | Radhakrishnan Mahalakshmi,SR Raghothama,Kamlesh Madhusudan Makwana | Stabilizing effect of electrostatic vs aromatic interactions in diproline nucleated peptide beta-hairpins. | 486 | Phys. Chem. Chem. Phys. | 2013 |
| 59 | Radhakrishnan Mahalakshmi,Muralikrishna Lella | Pro-Gly mediated conformational switch of Mycobacteriophage D29 holin transmembrane domain I is lipid concentration driven. | 487 | Chemical Communications | 2013 |
| 60 | Radhakrishnan Mahalakshmi,Deepti Chaturvedi | Methionine Mutations of Outer Membrane Protein X Influence Structural Stability and beta-Barrel Unfolding. | 488 | PLoS One | 2013 |
| 61 | Deepti Chaturvedi,Radhakrishnan Mahalakshmi,Ankit Gupta | Modified CNBr cleavage protocol for efficient separation of Met-Ser containing OmpX-Om14 membrane protein fusion | 483 | Intl. Rev. Biophys. Chem. | 2012 |
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