Prof sanjeev shukla

Professor
sanjeevs@iiserb.ac.in
Phone: +91 755 269 1409
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Professor (October 2023- Present), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
Associate Professor (April 2018- September 2023), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
Assistant Professor (May 2013-April 2018): Biological Sciences, Indian Institute of Science, Education and Research (IISER) Bhopal
Postdoctoral Fellow (March 2010-March 2013): National Cancer Institute, National Institutes of Health, Maryland, USA
Postdoctoral Fellow (May 2009-Feb 2010): Georgetown University Medical Centre, Washington DC, USA
Ph.D. (Nov 2003-Feb 2009): Advanced Centre for Treatment, Research and Education in Cancer (CRI-ACTREC), Navi Mumbai
December 2020, SERB STAR April 2017-March 2023: Wellcome Trust/ DBT India Alliance Intermediate Fellow
April 2017 Wellcome Trust/ DBT India Alliance Intermediate Fellow
Examination of DNA methylation mediated regulation of alternative splicing via modulation of reciprocal binding of CTCF and BORIS in cancer cells.
Analysis of DNA binding proteins/ transcription factors and upstream pathways that are involved in regulation of alternative splicing
Examination of role of cancer specific alternative spliced isoforms in tumorigenesis
SNo Authors Title of Article Pid Journal Year
1 Parik Kakani,Shrutu G Dhamdhere,Deepak Pant,Rushikesh Joshi,Jharna Mishra,Atul Samaiya,Sanjeev Shukla 1 Kakani P, Dhamdhere S, Pant D, Joshi R, Mishra J, Samaiya A, Shukla S*. “Hypoxia-induced CTCF promotes EMT in breast cancer 6421 Cell Reports 2024
2 Anchala Pandey,Parik Kakani,Sanjeev Shukla CTCF and BORIS-mediated autophagy regulation via alternative splicing of BNIP3L in breast cancer 6423 Journal of Biological Chemistry 2024
3 Palma FR,Gantner BN,Sakiyama MJ,Kayzuka C,Shukla S,Lacchini R,Cunniff B,Bonini MG ROS production by mitochondria: function or dysfunction? 5451 Oncogene 2024
4 Yadav P,Pandey A,Kakani P,Mutnuru A S,Samaiya A,Mishra J,Shukla S Hypoxia-induced loss of SRSF2-dependent DNA methylation promotes CTCF-mediated alternative splicing of VEGFA in breast cancer 4911 iScience 2023
5 Madhura R Pandkar,Adarsh Raveendran,Kajal Biswas,Srinivas Abhishek Mutnuru,Jharna Mishra,Atul Samaiya,Tyler Malys,Alexander Y Mitrophanov,Shyam K Sharan,Sanjeev Shukla PKM2 dictates the poised chromatin state of PFKFB3 promoter to enhance breast cancer progression 4913 NAR Cancer 2023
6 Madhura R Pandkar,Sommya Sinha,Atul Samaiya,Sanjeev Shukla Oncometabolite lactate enhances breast cancer progression by orchestrating histone lactylation-dependent c-Myc expression 4915 Translational Oncology 2023
7 Mishra T,Bhardwaj V,Ahuja N,Gadgil P,Ramdas P,Shukla S,Chande A Improved loss-of-function CRISPR/Cas9 genome editing in human cells concomitant with inhibition of TGF? signaling. 4903 Molecular Therapy - Nucleic Acids 2022
8 Mishra T,Dalavi R,Joshi G,Kumar A,Pandey P,Shukla S,Mishra K R,Chande A The role of SARS CoV-2 spike NTD mutations in determining neutralization susceptibility and virion infectivity 4905 Life Science Alliance 2022
9 Reddy C N,Molla R,Joshi N P,Sajeev K T,Basu I,Kawadkar J,Kalra N,Mishra K R,Chakrabarty S,Shukla S,Rai V Traceless cysteine-linchpin enables precision engineering of lysine in native proteins 4907 Nature Communications ( Open Access from 2016) 2022
10 Thakur K,Sajeev K T,Singh K S,Ragendu V,Rawale G D,Adusumalli R S,Kalra N,Shukla S,Mishra K R,Rai V Human Behavior-Inspired Linchpin-Directed Catalysis for Traceless Precision Labeling of Lysine in Native Proteins 4909 Bioconjugate Chemistry 2022
11 Subhashis Natua,Shruti Ganesh Dhamdhere,Srinivas Abhishek Mutnuru,Sanjeev Shukla Interplay within tumor microenvironment orchestrates neoplastic RNA metabolism and transcriptome diversity 3091 WIREs RNA 2021
12 Atul Samaiya,Jharna Mishra,Subhashis Natua,Neha Ahuja,Cheemala Ashok,Sanjeev Shukla E2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression 3131 Oncogenesis 2021
13 Anchala Pandey,Pooja Yadav,Sanjeev Shukla Unfolding the role of autophagy in the cancer metabolism 3439 Biochem. & Biophy. Reports 2021
14 Sandhya Yadav,Deepak Pant,Atul Samaiya,Neetu Kalra,Sanjay Gupta,Sanjeev Shukla ERK1/2-EGR1-SRSF10 Axis Mediated Alternative Splicing Plays a Critical Role in Head and Neck Cancer 3197 Frontiers in Cell and Developmental Biology 2021
15 Shubhashis Natua,Ashok Cheemala,Sanjeev Shukla Hypoxia-induced alternative splicing in human diseases: the pledge, the turn, and the prestige 2447 Cell and Molecular Life Sciences 2021
16 Arpankumar Choksi,Apoorva Parulekar,Richa Pant,Vibhuti Kumar Shah,Ramakrishna Nimma,Priyanka Firmal,Smriti Singh,Gopal C. Kundu,Sanjeev Shukla, Samit Chattopadhyay Tumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1 3021 BMC Cancer & Metabolism 2021
17 Madhura R Pandkar,Shruti G Dhamdhere,Sanjeev Shukla Oxygen gradient and tumor heterogeneity: The chronicle of a toxic relationship 3025 BBA Reviews on Cancer 2021
18 Atul Samaiya,Sanjeev Shukla,Jharna Mishra,Vishnu Narayanan SS,Pooja Yadav,Madhura R Pandkar,Anna Cherian,Deepak Pant,Subhashis Natua,Cheemala Ashok,Neha Ahuja Hypoxia-induced TGFb-RBFOX2-ESRP1 axis regulates human MENA alternative splicing and promotes EMT in breast cancer 2337 NAR Cancer 2020
19 Deepak Pant,Sathiya P Narayanan ,Nagarjun Vijay,Sanjeev Shukla Hypoxia-induced changes in intragenic DNA methylation correlate with alternative splicing in breast cancer 2095 Journal of Biosciences 2020
20 S R Adusumalli,D G Rawale,K Thakur,L Purushottam,N C Reddy,N Kalra,S Shukla,V Rai Chemoselective and Site‐Selective Lysine‐Directed Lysine Modification Enables Single‐Site Labeling of Native Proteins 2097 Angewandte Chemie International Edition 2020
21 Atul Samaiya,Jharna Mishra,Archana P T,Sandhya Yadav,Amit Gupta,Sanjeev Shukla HNRNP2B1-MST1R-AKT axis contributes to the EMT in head and neck cancer 2225 Nature Laboratory Investigation 2020
22 M Chilamari,N Kalra,S Shukla,Rai Vishal Single-site labeling of lysine in proteins through a metal-free multicomponent approach 1335 Chemical Communications 2018
23 S R Adusumalli ,D G Rawale ,U Singh,P Tripathi,R Paul,N Kalra,R K Mishra,S Shukla,V Rai Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology 1336 J.Am.Chem.Soc 2018
24 Sanjeev Shukla,Atul Samaiya,Rajendra Kumar Panday,Smriti Singh,Athira Ajith,Amit Gupta PAK2–c-Myc–PKM2 axis plays an essential role in head and neck oncogenesis via regulating Warburg effect 1202 Cell Death and Disease 2018
25 Sathiya Pandi Narayanan,Smriti Singh,Sanjeev Shukla A saga of cancer epigenetics: linking epigenetics to alternative splicing 674 Biochemical J 2017
26 Atul Samaiya,Rajendra Kumar Panday,Sandhya Yadav,Neha Ahuja,Amit Gupta,Kajal Biswas,Sathiya Pandi Narayanan,Smriti Singh,Shyam K Sharan,Sanjeev Shukla Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect 965 Proceedings of the National Academy of Sciences 2017
27 Nazmul Haque,Sanjeev Shukla,Kyster K Nanan,Maria F Prigge,Garima Verma,Morgan Thenoz,Marc A Bailly,David Sturgill,Ryan J Marina,Shalini Oberdoerffer TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing 134 EMBO J 2016
28 Sathiya Pandi Narayanan,Smriti Singh,Amit Gupta,Sandhya Yadav,Shree Ram Singh,Sanjeev Shukla Integrated genomic analyses identify KDM1A’s role in cell proliferation via modulating E2F signaling activity and associate with poor clinical outcome in oral cancer 133 Cancer Letters 2015
29 Sanjeev Shukla,E Kavak ,M Gregory ,M Imashimizu , B Shutinoski,M Kashlev ,P Oberdoerffer ,R Sandberg,S Oberdoerffer CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing 4917 Nature ( Through e-Shodh Sindhu) 2011